Mouse Interleukin-17F(IL17F) ELISA kit

Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway. Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes.

1. our results indicate that Th17 cells contribute to the airway vascular remodeling in asthma by mediating EPC chemotaxis, as well as PMVEC tube formation, via IL-17A rather than IL-17F. PMID: 25780043
2. Data indicate that IL-17A repressed IL-17F secretion in vitro and in vivo. PMID: 24600029
3. The concentrations in plasma of IL-17A, IL-17F, and the IL-17AF heterodimer all were increased greatly in mice after endotoxemia. PMID: 23499051
4. IL-17A and IL-17F secreted by CD4+Th17 cells specific to lung self-antigens are critical mediators of autoimmunity leading to the pathogenesis of obliterative airway disease. PMID: 23325004
5. The Th17 subset of T-lymphocytes produces IL-17F to stimulate bone healing. PMID: 22768215
6. IL-17F is not required for development of T helper cell (Th)2-type allergic airway inflammation. PMID: 22942422
7. Together, our findings demonstrate a protective role for IL-17F in colon cancer development, possibly via inhibiting tumor angiogenesis PMID: 22509371
8. These results demonstrate that IL-17A/F plays a critical role in Legionella pneumophila pneumonia, probably through induction of proinflammatory cytokines and accumulation of neutrophils at the infection site. PMID: 22144493
9. CNS2 is sufficient and necessary for Il17 and optimal Il17f gene transcription in Th17 cells PMID: 22244845
10. IL-17F was produced in peritoneal macrophages after TLR4 activation, peaking after 12 h. This effect was completely dependent on the presence of MyD88. The copresence of the complement activation product C5a amplified IL-17F production. PMID: 21859896
11. This work demonstrates the important roles of both IL-17 signaling and neutrophils in clearing this pathogen and surviving pulmonary Bacillus anthracis infection. PMID: 22025514
12. these results suggest the proinflammatory and essential role of IL-17F to develop spontaneous intestinal tumorigenesis in Apc(Min/+) mice in the presence of IL-17A. PMID: 21939640
13. Data show that Mel-18 and Ezh2 positively regulate the expression of Il17a and Il17f. PMID: 21674483
14. Increased resistance to infection in a mouse model of tularemia was associated with a specific increase in IL-17A/F PMID: 20176744
15. IL-17A and IL-17F induce the production of chemokines MCP-1 and MIP-2 via MAPK pathways (p38 MAPK and ERK1/2), as well as mRNA transcription and protein translation and have synergistic effects with TNF-alpha and IL-1beta in cultured mesangial cells. PMID: 20042461
16. Intranasal administration of adenovirus expressing IL-17F results in bronchoalveolar lavage neutrophilia and inflammatory gene expression in the lung. PMID: 12077275
17. a role for IL-17F in the induction of neutrophilia in the lungs and in the exacerbation of Ag-induced pulmonary inflammation. PMID: 15477493
18. THi cell differentiation is associated with epigenetic changes in the IL-17-IL-17F locus, which suggests novel mechanisms in T cell functional regulation. PMID: 17218320
19. study found that THi cells upon stimulation produce not only IL-17 and IL-17F homodimers but also the IL-17A/F heterodimer; IL-17A/F cytokine represents another mechanism whereby T cells regulate inflammatory responses PMID: 17452998
20. In sham-challenged mice, IL-17F was not expressed in the lungs, while, in contrast, IL-17F was predominantly expressed in bronchial epithelial cells in addition to the infiltrating inflammatory cells in OVA/OVA mice. IL-17F mayplay a role in asthma. PMID: 17541285
21. IL-17F is an important regulator of inflammatory responses that seems to function differently than IL-17 in immune responses and diseases. PMID: 18411338
22. IL-17F/IL-17R interaction stimulates granulopoiesis in mice. PMID: 18723265
23. IL-17F may be involved in psoriasis via, in part, the activation of ERK1/2 and the induction of IL-8 in keratinocytes PMID: 18830271
24. RORgamma controls IL-17A and IL-17F production, and these cytokines have a redundant but highly pathogenic role in gut inflammation. PMID: 18992745
25. Both IL-17A and IL-17F can signal via the IL-17RA; however, IL-17F does so at a 1- to 2-log higher concentration than IL-17A. PMID: 19017936
26. Data suggest that both IL-17A and IL-17F, while prominently expressed by an encephalitogenic T cell population, may only marginally contribute to the development of autoimmune CNS disease. PMID: 19075395
27. IL-17F and IL-17A were involved in host defense against mucoepithelial infection by Staphylococcus aureus and Citrobacter rodentium. IL-17A was produced mainly in T cells, whereas IL-17F was produced in T cells, innate immune cells, and epithelial cells PMID: 19144317
28. IL-17A mediated suppression of IL-17F production and secretion requires IL-17RA and is relevant to maintain the normal set point of blood neutrophil counts in vivo PMID: 19542376
29. T cells lacking Itk exhibit decreased interleukin-17A expression in vitro and in vivo, despite relatively normal expression of retinoic acid receptor-related orphan receptor-gammaT and IL-17F. PMID: 19818650

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Secreted.

IL-17 family

Expressed by T-helper 17 cells (Th17) (at protein level). The expression pattern reflects the differentiation state. In fully differentiated Th17 cells, IL17A-IL17F heterodimers are produced at higher levels than IL17A-IL17A and IL17F-IL17F dimers. Domina

KEGG: mmu:257630

STRING: 10090.ENSMUSP00000046960

UniGene: Mm.222807