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Mouse Insulin-like growth factor-binding protein 7(IGFBP7) ELISA kit

  • 中文名称:
    小鼠胰岛素样生长因子结合蛋白7(IGFBP7)酶联免疫试剂盒
  • 货号:
    CSB-EL011101MO
  • 规格:
    96T/48T
  • 价格:
    ¥3600/¥2500
  • 其他:

产品详情

  • 产品描述:
    小鼠胰岛素样生长因子结合蛋白7(IGFBP7)酶联免疫试剂盒(CSB-EL011101MO)为双抗夹心法ELISA试剂盒,定量检测血清、血浆,组织匀浆样本中的IGFBP7含量。IGFBP7 是一种重要的靶点。它在细胞生长、增殖等生理过程中发挥作用,与肿瘤的发生发展密切相关。研究机制上,主要聚焦其与 IGF 轴的相互作用,以及对细胞信号通路的调控等,深入研究有望为相关疾病治疗提供新思路。试剂盒检测范围为12.5 pg/mL-800 pg/mL,该产品适用于科研领域对IGFBP7的定量研究,例如探索其在疾病模型中的动态变化、评估药物干预效果或解析相关信号通路机制,为心血管疾病、肿瘤微环境及组织修复等基础研究提供可靠工具本品仅用于科研,不用于临床诊断,产品具体参数及操作步骤详见产品说明书。
  • 别名:
    Igfbp7 ELISA Kit; Mac25Insulin-like growth factor-binding protein 7 ELISA Kit; IBP-7 ELISA Kit; IGF-binding protein 7 ELISA Kit; IGFBP-7 ELISA Kit; MAC25 protein ELISA Kit
  • 缩写:
    IGFBP7
  • Uniprot No.:
  • 种属:
    Mus musculus (Mouse)
  • 样本类型:
    serum, plasma,tissue homogenates
  • 检测范围:
    12.5 pg/mL-800 pg/mL
  • 灵敏度:
    3.12 pg/mL
  • 反应时间:
    1-5h
  • 样本体积:
    50-100ul
  • 检测波长:
    450 nm
  • 研究领域:
    Signal Transduction
  • 测定原理:
    quantitative
  • 测定方法:
    Sandwich
  • 数据处理:
  • 货期:
    3-5 working days

产品评价

靶点详情

  • 功能:
    Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
  • 基因功能参考文献:
    1. Our findings define an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses hepatocellular carcinoma PMID: 28619711
    2. Study shows that IGFBP7 contributes significantly to mesenchymal stromal cells (MSC)-mediated immune modulation, as is shown by decreasing ability of IGFBP7 knockdown in MSCs to restore proliferation and cytokine production in T-cells. PMID: 27397633
    3. data suggest that IGFBP-7 was up regulated during EAE and inhibit the transition from OPCs to mature OLs, implying its use as a potential therapeutic target for the treatment of inflammatory demyelinating diseases PMID: 25819415
    4. Our data suggest that loss of Igfbp7 induces precocious involution possibly through diminished cell survival signals. PMID: 24505323
    5. Angiomodulin is necessary for cardiac commitment of embryonic stem cells (ESCs) and its regulation depends on TAp63 isoform. PMID: 24145187
    6. a model whereby IGFBP7 binds to unoccupied IGF1R and suppresses downstream signaling, thereby inhibiting protein synthesis, cell growth, and survival. PMID: 23250396
    7. IGFBP7 has a novel role in mouse uterus: it is regulating uterine receptivity through Th1/Th2 lymphocyte balance and decidualization. PMID: 23028860
    8. fear extinction-induced IGF2/IGFBP7 signalling promotes the survival of 17-19-day-old newborn hippocampal neurons PMID: 21873981
    9. Results demonstrate that the vascular-specific marker angiomodulin (AGM) modulates vascular remodeling in part by temporizing the proangiogenic effects of VEGF-A. PMID: 19542015
    10. study showed that IGFBP-rP1 (IGFBP7) was expressed in dysregulated podocytes in a human immunodeficiency virus-associated nephropathy model and in immature podocytes in the developing kidney; conclude that IGFBP-rP1 may be a product of injured podocytes PMID: 20630940
    11. Mac25 interacts with the extracellular matrix proteins and glycosaminoglycans that are expressed in most blood vessels including high endothelial venules, as well as with chemokines implicated in regulation of lymphocyte trafficking, e.g., SLC and IP-10. PMID: 12847218
    12. Proteolytic processing of mac25 modulates its insulin/IGF-1-dependent growth-stimulatory activity. PMID: 14521955
    13. IGFBP-7 can regulate glioma cell migration through the AKT-ERK pathway, thereby playing an important role in glioma growth and migration PMID: 19048112

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  • 亚细胞定位:
    Secreted.
  • 组织特异性:
    Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver.
  • 数据库链接:

    KEGG: mmu:29817

    UniGene: Mm.233470