Mouse Epidermal growth factor-like protein 7(EGFL7) ELISA kit

1. EGFL7 reduces CNS inflammation in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. PMID: 29483510
2. Egfl7 is crucial for placental vascularization and embryonic growth. PMID: 28526753
3. the angiogenic factor Egfl7 activates the Flt3/Flt3 ligand pathway and is a key molecular driver enforcing thymus progenitor generation and thereby directly links endothelial cell biology to the production of T cell-based adaptive immunity PMID: 28601636
4. EGFL7 is required for VEGF upregulation of the Akt/Erk (1/2) pathway during angiogenesis. PMID: 24647208
5. EGFL7 enhances EGFR-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells. PMID: 24945379
6. Egfl7 could be a HIF-1alpha responsive gene regulated by oxygen tension. PMID: 25539718
7. Using the BPH/5 model of pre-eclampsia (PE), we show that the downregulation of Egfl7 in compromised placentas occurs prior to the onset of characteristic maternal signs of PE. PMID: 24751645
8. egfl7 is initially expressed in all endothelial cells and then is progressively restricted to veins and to their neighbouring capillaries. PMID: 24595089
9. EGFL7 is expressed in the bone microenvironment and has a role in promoting endothelial cell migration and tube-like structure formation through integrin-mediated pathways. PMID: 24909139
10. Expression of Egfl7 in breast and lung carcinoma cells accelerates tumor growth and metastasis in immunocompetent mice but not in immunodeficient mice. PMID: 22037871
11. Overexpression of endothelial Egfl7 is associated with impaired angiogenesis and altered Notch signaling PMID: 20947685
12. the expression of the VE-statin/egfl7 gene in endothelial cells and the specific importance of ETS and GATA factors PMID: 20808444
13. is the first identified inhibitor of mural cell migration specifically produced by endothelial cells. PMID: 14592969
14. regulator that controls a specific and important step in vasculogenesis PMID: 15085134
15. EGFL7 protein is localized to the endoplasmic reticulum and Golgi apparatus, suggesting that the protein is targeted for secretion PMID: 15162510
16. The recombinant protein is pure as assessed by SDS-PAGE, immunoblot and mass spectrometry, and is biologically active as a repressor of human aortic smooth muscle cell migration induced by platelet-derived growth factor-BB. PMID: 16169248
17. EGFL7 defines the optimal path of endothelial cells movement by assuring the correct positioning of each EC in a nascent sprout. PMID: 17626061
18. EGFL7 provides a proper microenvironment for endothelial cell migration, thereby enabling accurate patterning. PMID: 18300411
19. VE-statin/egfl7 produced by endothelial cells binds to the catalytic domains of enzymes of the LOX family in the vascular wall, thereby preventing the crosslink of tropoelastin molecules into mature elastin polymers and regulating vascular elastogenesis. PMID: 18497746
20. Results provide the first evidence of a non-endothelial expression of EGFL7 and suggest distinctive roles for Egfl7 in vascular development and germ cell differentiation. PMID: 18556249
21. demonstrate the regulation of angiogenesis by an endothelial miRNA, attribute previously described Egfl7 vascular phenotypes to miR-126, and document inadvertent miRNA dysregulation as a complication of knockout strategies PMID: 18987025
22. Data identified neurons as a source of EGFL7 in the brain, suggesting that brain-derived EGFL7 acts as an endogenous antagonist of Notch signalling that regulates proliferation and differentiation of subventricular zone-derived adult NSCs. PMID: 19503073
23. Egfl7 promotes metastasis of hepatocellular carcinoma (HCC) by enhancing cell motility through EGFR-dependent FAK phosphorylation. PMID: 19824075

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KEGG: mmu:353156

STRING: 10090.ENSMUSP00000099971

UniGene: Mm.268933