Mouse Cadherin-3(CDH3) ELISA kit
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中文名称：小鼠钙黏蛋白3(CDH3)酶联免疫试剂盒
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货号：CSB-EL005052MO
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规格：96T/48T
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价格：￥3600/￥2500
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其他：
产品详情
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产品描述：小鼠钙黏蛋白3(CDH3)酶联免疫试剂盒（CSB-EL005052MO）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的CDH3含量。CDH3是一种重要靶点。其背景在于在多种生理与病理过程中发挥关键作用，尤其在肿瘤发生发展里常异常表达。研究机制方面，主要聚焦于其在细胞黏附、信号传导等过程的作用，探索通过干预它来抑制肿瘤生长、转移等的策略。试剂盒检测范围为78 pg/mL-5000 pg/mL，灵敏度为19.5 pg/mL。本试剂盒通过特异性抗体对实现高灵敏检测，适用于小鼠模型中CDH3蛋白表达水平的动态监测，可广泛用于肿瘤生物学、胚胎发育或炎症微环境等领域的基础研究。科研人员可通过深入探究CDH3在细胞迁移调控、上皮间质转化等分子机制中的作用，为疾病相关信号通路研究提供可靠工具。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
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别名：Cdh3; Cdhp; Cadherin-3; Placental cadherin; P-cadherin
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缩写：
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Uniprot No.：
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种属：Mus musculus (Mouse)
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样本类型：serum, plasma, tissue homogenates
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检测范围：78 pg/mL-5000 pg/mL
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灵敏度：19.5 pg/mL
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Neuroscience
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测定原理：quantitative
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测定方法：Sandwich
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数据处理：
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货期：3-5 working days
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靶点详情
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功能：Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
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基因功能参考文献：
- P-Cadherin is not required for maintenance of retinal stem cells in vivo. PMID: 28494434
- P-cadherin (CDH3) is highly dominant in both mouse and human retinal pigment epithelium in situ. The degree of dominance of P-cadherin is surprisingly large, with mouse Cdh3 and human CDH3 accounting for 82-85% and 92-93% of the total of the three cadherin mRNAs, respectively. PMID: 29338041
- P-cadherin is a direct PAX3-FOXO1A transcriptional target involved in Alveolar rhabdomyosarcoma aggressiveness. PMID: 22710718
- Loss of P-cadherin is associated with melanoma. PMID: 21445019
- UVB exposure resulted in the overexpression of the cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and the adhesion molecule P-cadherin. PMID: 20212509
- Truncated P-cadherin promotes melanoma cell invasion and migration and therefore has an important role in the progression of malignant melanoma. PMID: 16919267
- P-cadherin is a newly defined transcriptional target gene of p63, with a crucial role in hair follicle morphogenesis as well as the apical ectodermal ridge during limb bud outgrowth in humans whereas it is not required for either in mice. PMID: 18199584
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亚细胞定位：Cell membrane; Single-pass type I membrane protein.
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数据库链接：
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