Mouse Apolipoprotein A-I-binding protein(APOA1BP) ELISA kit

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.

1. Loss of Apoa1bp increased vascular density and facilitated the recovery of blood vessel perfusion function in a hindlimb ischemia model. PMID: 28325782
2. The Aibp gene encodes two different proteins, both targeted to the mitochondria (mAIBP) and cytosol (cAIBP) confirming the presence of dehydratase and epimerase in the cytosol and mitochondria. PMID: 24611804
3. AI-BP plays an important role in capacitation possibly providing a link between protein phosphorylation and cholesterol efflux. PMID: 18202122

Mitochondrion. Secreted. Note=In sperm, secretion gradually increases during capacitation.

NnrE/AIBP family

Detected in testis and sperm (at protein level). Expressed at high levels in heart, liver, kidney, and testis.

KEGG: mmu:246703

STRING: 10090.ENSMUSP00000029708

UniGene: Mm.205996