Monkey Apolipoprotein(a) (LPA) ELISA kit

产品详情

产品描述：

猴载脂蛋白α(LPA)酶联免疫试剂盒（CSB-EL013044RH）为竞争法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的LPA含量。猴载脂蛋白α（LPA）是一种与心血管疾病风险相关的蛋白质，其表达水平受基因调控。研究发现，LPA通过其特定的结构域与低密度脂蛋白（LDL）结合，形成脂蛋白(a)（Lp(a)），增加心血管疾病风险。目前，针对LPA的研究主要集中在开发能够抑制其表达或阻断其与LDL结合的药物，以降低心血管疾病风险。试剂盒检测范围为31.25 ng/mL-2000 ng/mL，适用于灵长类动物模型中脂代谢调控、心血管疾病机制、药物干预效果评估等基础研究，为科研人员提供稳定可靠的LPA蛋白表达水平分析工具。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
别名：

LPAApolipoprotein(a ELISA kit; Apo(a) ELISA kit; Lp(a) ELISA kit; EC 3.4.21.- ELISA kit; Fragment ELISA kit
缩写：

Lp-α, LPA
Uniprot No.：

P14417
种属：

Monkey
样本类型：

serum, plasma, tissue homogenates
检测范围：

31.25 ng/mL-2000 ng/mL
灵敏度：

15.63 ng/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Cardiovascular
测定原理：

quantitative
测定方法：

Competitive

精密度：

Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.

标准曲线：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

功能：

Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.
相关疾病：

Elevated plasma concentrations of apo(a) and its naturally occurring proteolytic fragments are correlated with atherosclerosis. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.
蛋白家族：

Peptidase S1 family, Plasminogen subfamily
数据库链接：

STRING: 9544.ENSMMUP00000021286

UniGene: Mmu.3290