Human monocyte chemotactic protein 4,MCP-4 ELISA kit
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中文名称:人单核细胞趋化蛋白4(MCP-4/CCL13)酶联免疫试剂盒
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货号:CSB-E09762h
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规格:96T/48T
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价格:¥3600/¥2500
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其他:
产品详情
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产品描述:本试剂盒(CSB-E09762h)采用双抗体夹心法原理,专为定量检测人血清、血浆或组织匀浆样本中单核细胞趋化蛋白4(MCP-4/CCL13)水平而设计。MCP-4/CCL13属于CC趋化因子家族成员,通过与CCR2/CCR3受体结合参与免疫细胞迁移及炎症反应调控,在哮喘、过敏性炎症及自身免疫性疾病等病理过程中具有重要研究价值。该试剂盒检测范围为39-2500 pg/ml,可精准覆盖生理及病理状态下样本中的靶标浓度,其标准曲线采用梯度浓度校准品建立,确保实验数据的线性可靠性。产品适用于体外研究领域,包括炎症机制探索、疾病模型建立、药物干预效果评估等基础科研场景,例如通过检测不同实验条件下生物样本中MCP-4/CCL13的动态变化,揭示其在免疫调节网络中的作用机制。操作流程严格遵循ELISA技术规范,配套试剂包含预包被抗体、检测抗体及显色系统,适用于常规实验室条件下的高通量分析需求。
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别名:C-C motif chemokine 13 ELISA Kit; CCL13 ELISA Kit; CCL13_HUMAN ELISA Kit; Chemokine (C C motif) ligand 13 ELISA Kit; CK beta 10 ELISA Kit; CK-beta-10 ELISA Kit; CKb10 ELISA Kit; MCP-4 ELISA Kit; MGC17134 ELISA Kit; Monocyte chemoattractant protein 4 ELISA Kit; Monocyte chemotactic protein 4 ELISA Kit; NCC 1 ELISA Kit; NCC-1 ELISA Kit; NCC1 ELISA Kit; New CC chemokine 1 ELISA Kit; SCYA13 ELISA Kit; SCYL1 ELISA Kit; short chain ELISA Kit; Small inducible cytokine A13 precursor ELISA Kit; Small inducible cytokine subfamily A (Cys Cys) member 13 ELISA Kit; Small-inducible cytokine A13 ELISA Kit
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缩写:
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Uniprot No.:
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种属:Homo sapiens (Human)
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样本类型:serum, plasma, tissue homogenates.
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检测范围:39 pg/ml-2500 pg/ml.
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灵敏度:9.75 pg/ml.
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Immunology
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测定原理:quantitative
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测定方法:Sandwich
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数据处理:
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货期:3-5 working days
相关产品
靶点详情
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功能:Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
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基因功能参考文献:
- CCL13 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
- CCL13 levels in serum and synovial fluid may serve as a biomarker for the progression of osteoarthritis. PMID: 25654294
- CCL13 is an antimicrobial protein with bacteriocidal activity against E. coli. PMID: 12949249
- Data suggest that CCL13 binds to several chemokine receptors (CCR1, CCR2, and CCR3), allowing CCL13 to elicit different effects on target cells of immune system. CCL13 is involved in pathology of chronic inflammatory/autoimmune diseases. [REVIEW] PMID: 23846739
- MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease. PMID: 23375121
- E(2) has adverse effects on the pathogenesis of RA as a result of unregulated cell death, increased TNF-alpha-induced MMP-3 production, and CCL13 overproduction, subsequently resulting in the disease progression of RA. PMID: 22393877
- Findings suggest that the pro-atherogenic effects of CCR2 may not be restricted to interaction with MCP-1, but could also involve activation by MCP-4, being an inflammatory link between platelet and monocyte activation. PMID: 20139115
- Data suggest that the monocyte chemoattractant protein-4 core promoter YY-1 binding motif is functional, and modulates the transcriptional regulation of the MCP-4 gene. PMID: 12805085
- The study was undertaken to understand the relationship between the functional proteomics of receptor-Ck and developmental stages of human atherosclerotic aortic wall. PMID: 14560935
- MCP-4 may be a critical molecule that links obesity and chronic inflammation. PMID: 16855189
- The Th2 cytokine IL-4 preferentially stimulated MCP-4 expression. PMID: 17541284
- interferon-gamma with IL-1beta/TNF-alpha activates the production of CCL13 from chondrocytes in RA joints; secreted CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated MAP kinases cascade PMID: 17824960
- TLR2, 3, 4 and 5 ligands, but not TLR7/8 or 9 ligands, synergized with IL-4 to induce the production of MCP-4 in nasal polyp fibroblasts. PMID: 17851891
- CCL13 and HSPC159 mRNA expressions in PBMC are up-regulated specifically in MCNS patients during the nephrosis phase. PMID: 18219197
- Oncostatin M can strongly up-regulate the expression of CCL13, a chemokine recently identified in the synovial fluid of patients with rheumatoid arthritis. PMID: 19565514
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亚细胞定位:Secreted.
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蛋白家族:Intercrine beta (chemokine CC) family
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组织特异性:Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
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数据库链接:
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