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Human amyloid beta peptide 1-40,Aβ1-40 ELISA Kit

文献引用 (11) 说明书下载

中文名称：

人β淀粉样蛋白1-40(Aβ1-40)酶联免疫试剂盒
货号：

CSB-E08299h
规格：

96T/48T
价格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

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产品描述：

本试剂盒专为定量检测人血清、组织匀浆及脑脊液（CSF）中的β淀粉样蛋白1-40（Aβ1-40）而设计，该蛋白是阿尔茨海默病等神经退行性疾病的重要研究靶点，其异常聚集形成的淀粉样斑块与神经元损伤密切相关。产品采用双抗体夹心法原理，通过高特异性抗体对实现精准定量分析，检测范围覆盖125 pg/mL至8000 pg/mL，满足低丰度样本检测需求。实验操作兼容多种生物样本类型，特别适用于脑脊液等微量样本中Aβ1-40的动态监测。该试剂盒可广泛应用于神经退行性疾病机制研究、药物开发中淀粉样蛋白调控效果评估、以及脑脊液生物标志物谱分析等科研领域，为探索Aβ1-40在病理过程中的分子作用提供可靠工具。试剂盒包含预包被板、标准品、检测抗体及显色系统，实验流程优化后可在4.5小时内完成检测，具备良好的重复性与灵敏度。
别名：

amyloid beta peptide 1-40,Aβ1-40,amyloid β peptide 1-40
缩写：

Aβ1-40
种属：

Homo sapiens (Human)
样本类型：

serum, tissue homogenates, cerebrospinal fluid (CSF)
检测范围：

125 pg/mL-8000 pg/mL
灵敏度：

31.25 pg/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Neuroscience
测定原理：

quantitative
测定方法：

Sandwich

精密度：

Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.

线性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human Aβ1-40 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
		Sample		Serum(n=4)
1:1		Average %		87
		Range %		80-92
1:2		Average %		99
		Range %		91-105
1:4		Average %		95
		Range %		92-98
1:8		Average %		103
		Range %		96-110

回收率：

The recovery of human Aβ1-40 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type		Average % Recovery		Range
Serum (n=5)		98		89-100

标准曲线：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
8000	2.846	2.687	2.767	2.610
4000	2.237	2.089	2.163	2.006
2000	1.679	1.612	1.646	1.489
1000	1.246	1.211	1.229	1.072
500	0.736	0.697	0.717	0.560
250	0.512	0.498	0.505	0.348
125	0.303	0.296	0.300	0.143
0	0.160	0.154	0.157

数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

引用文献

GNG5 is a novel regulator of Aβ42 production in Alzheimer's disease C Li, Y Yang, S Luo, W Qiu, X Wang, W Ge,Cell Death & Disease,2024
Oab-14 Alleviates Mitochondrial Impairment Through the Sirt3-Dependent Mechanism in App/Ps1 Transgenic Mice and N2a/App Cells N Zheng, R Cao, D Liu, P Liu, X Zhao, S Zhang,Available at SSRN 5013649,/
Targeting blood brain barrier—Remote ischemic conditioning alleviates cognitive impairment in female APP/PS1 rats Y Ma,CNS neuroscience & therapeutics,2024
The aldehyde dehydrogenase 2 rs671 variant enhances amyloid β pathology X Wang,Nature communications,2024
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization D Yao,Translational psychiatry,2023
Extracellular Vesicles Play a Central Role in Cerebral Venous Disease‐Associated Brain Atrophy JY Wang,Advanced science,2023
Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model M Hu,Nature communications,2023
Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway X Wang,Biomedicine & pharmacotherapy,2023
Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin C Qian,Research Square,2021
Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology Jiang X, et al,Journal of Ethnopharmacology,2019
Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease Ya-Ru Wen.et al,NRR,2018

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■ 常见问题解答

Q:

We are interested in this kit.Could you let me know the information about the following ?
Do you have the information of capture antibody coated on the plate and biotinylated detection antibody in the kit?

A:

Thanks for your inquiry.
Capture antibody:mouse monoclonal antibody;Detection antibody:goat polyclonal antibody.

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九游平台-九游(中国) | 米兰体育-米兰体育（中国） | 开云手机在线登陆入口 | 江南官方体育网页版 | 开云网页版 | 开云官方在线入口 | 开云电子体育 | 开云官方链接 | 江南网页版页面登录 |