Human WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2(WFIKKN2) ELISA kit

说明书下载

中文名称：

人WAP，kazal，免疫球蛋白，kunitz和NTR结构域蛋白2(WFIKKN2)酶联免疫试剂盒
货号：

CSB-EL026099HU
规格：

96T/48T
价格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

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产品描述：

人WAP，kazal，免疫球蛋白，kunitz和NTR结构域蛋白2(WFIKKN2)酶联免疫试剂盒（CSB-EL026099HU）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的WFIKKN2含量。WFIKKN2是一种新的TGF-β家族成员的胞外结合蛋白，高表达于卵巢和睾丸，与TGF-β家族成员如MSTN、GDF11、TGF-β1、BMP2和BMP4等结合，通过调节这些因子的功能来正向或负向调控生殖细胞发生。其具体作用机制涉及阻断SMAD信号通路，激活非经典途径，以及与生殖细胞发育相关。试剂盒检测范围为31.25 pg/mL-2000 pg/mL，灵敏度为7.81 pg/mL。适用于细胞生物学、分子病理学等科研领域，可应用于炎症相关疾病模型、肿瘤微环境研究或发育生物学中WFIKKN2蛋白表达动态监测，为探索其分子功能提供可靠工具。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
别名：

WFIKKN2 ELISA Kit; GASP1 ELISA Kit; WFIKKNRP ELISA Kit; UNQ9235/PRO31996 ELISA Kit; WAP ELISA Kit; Kazal ELISA Kit; immunoglobulin ELISA Kit; Kunitz and NTR domain-containing protein 2 ELISA Kit; Growth and differentiation factor-associated serum protein 1 ELISA Kit; GASP-1 ELISA Kit; hGASP-1 ELISA Kit; WAP ELISA Kit; follistatin ELISA Kit; immunoglobulin ELISA Kit; Kunitz and NTR domain-containing-related protein ELISA Kit; WFIKKN-related protein ELISA Kit
缩写：

WFIKKN2
Uniprot No.：

Q8TEU8
种属：

Homo sapiens (Human)
样本类型：

serum, plasma, tissue homogenates
检测范围：

31.25 pg/mL-2000 pg/mL
灵敏度：

7.8 pg/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Cell Biology
测定原理：

quantitative
测定方法：

Sandwich
数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

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功能：

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin.
基因功能参考文献：
1. WFIKKN2 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
2. After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed higher levels of GASP-1 while postmenopausal women using HT showed a significant increased expression over controls. PMID: 22395277
3. Creatine supplementation in conjunction with resistance training lead to greater decreases in serum myostatin (p<0.05), but had not additional effect on GASP-1 (p>0.05). PMID: 20026378
4. Newly discovered WFIKKNPR gene structure and tissue distribution of gene expression is commpared with that of the WFIKKN gene in adult and fetal tissues and organs PMID: 11928817
亚细胞定位：

Secreted.
蛋白家族：

WFIKKN family
组织特异性：

Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney.
数据库链接：

HGNC: 30916

OMIM: 610895

KEGG: hsa:124857

STRING: 9606.ENSP00000311184

UniGene: Hs.211475

Human WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2(WFIKKN2) ELISA kit

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