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  4. Human Tetranectin(CLEC3B) ELISA kit

Human Tetranectin(CLEC3B) ELISA kit

说明书下载
  • 中文名称：
    人四连接素(CLEC3B)酶联免疫试剂盒
  • 货号：
    CSB-EL005531HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：
CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

产品详情

  • 产品描述：
    人四连接素(CLEC3B)酶联免疫试剂盒（CSB-EL005531HU）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的CLEC3B含量。人四连接素（CLEC3B）是一种钙离子依赖性凝集素，参与细胞黏附、分化调控及肿瘤抑制。其与纤溶酶原和kringle 4结合，可能涉及胞吐作用相关分子包装和眼部生理学。研究显示，CLEC3B在多种癌症中表达下调，与肿瘤侵袭、转移和免疫微环境相关，具有潜在的诊断和预后价值。试剂盒检测范围为1.56 ng/ml- 100 ng/ml，灵敏度为0.39 ng/ml。支持科研人员在体外实验中高效检测目标蛋白的表达变化，适用于基础医学研究中疾病机制探索、生物标志物筛选以及药物干预效果评估等场景。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
  • 别名：
    C type lectin domain family 3 member B ELISA Kit; C-type lectin domain family 3 member B ELISA Kit; Clec3b ELISA Kit; Plasminogen kringle 4 binding protein ELISA Kit; Plasminogen kringle 4-binding protein ELISA Kit; TETN_HUMAN ELISA Kit; Tetranectin (plasminogen binding protein) ELISA Kit; Tetranectin ELISA Kit; TN ELISA Kit; TNA ELISA Kit
  • 缩写：
    CLEC3B
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    1.56 ng/ml- 100 ng/ml
  • 灵敏度：
    0.39 ng/ml
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Others
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 线性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of human CLEC3B in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:100

    Average %

    107

    Range %

    103-112

    1:200

    Average %

    101

    Range %

    94-107

    1:400

    Average %

    95

    Range %

    88-101

    1:800

    Average %

    99

    Range %

    94-105

  • 回收率：

    The recovery of human CLEC3B spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    95

    89-100

    EDTA plasma (n=4)

    99

    92-106

  • 标准曲线：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    100

    2.861

    2.734

    2.798

    2.655

    50

    1.897

    1.867

    1.882

    1.739

    25

    1.111

    1.058

    1.084

    0.942

    12.5

    0.649

    0.629

    0.639

    0.496

    6.25

    0.420

    0.399

    0.410

    0.267

    3.12

    0.290

    0.283

    0.287

    0.144

    1.56

    0.209

    0.204

    0.206

    0.064

    0

    0.141

    0.145

    0.143

    　

  • 数据处理：
    ELISA操作视频及标曲绘制软件下载
  • 货期：
    3-5 working days

产品评价

相关产品

CLEC3B antibodies

CLEC3B Proteins

靶点详情

  • 最新研究进展：
    CLEC3B是一种由CLEC3B基因编码的蛋白质，也被称为牙龈沟液蛋白GCP-2。CLEC3B在人体免疫系统中发挥着重要作用，可通过识别病原体或潜在损伤信号，介导免疫反应。最近的研究表明，CLEC3B还可能与其他生物学过程有关，如肝脏再生、炎症反应和肿瘤的生长和转移等。此外，CLEC3B的检测也被用于诊断某些疾病和监测其疾病进程。
     
  • 功能：
    Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis.
  • 基因功能参考文献：
    1. Low CLEC3B expression is associated with clear cell renal cell carcinoma. PMID: 30066941
    2. The present study identified the CLEC3B p.S106G as a novel longevity-associated variant, raising the novel hypothesis that tetranectin, encoded by CLEC3B, plays a role in human longevity and aging PMID: 27154906
    3. TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival PMID: 28718365
    4. study suggests that increased serum TN level is associated with the presence and severity of diseased coronary arteries in patients with stable CAD. PMID: 26621497
    5. results predict that a positive TN expression of both tumour tissue and serum points to a more favourable outcome for ovarian cancer patients PMID: 25846370
    6. analyze the immunohistochemical localization of tetranectin in gastric adenocarcinomas and the adjacent tissues of the wall of the stomach PMID: 11962752
    7. Tetranectin may play an important role in the survival of islets in the liver after islet transplantation. PMID: 15848710

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Found in plasma.
  • 数据库链接：

    HGNC: 11891

    OMIM: 187520

    KEGG: hsa:7123

    STRING: 9606.ENSP00000296130

    UniGene: Hs.476092

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