Human T-complex protein 1 subunit epsilon(CCT5) ELISA kit

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中文名称：

人T复合物蛋白1亚基ε(CCT5)酶联免疫试剂盒
货号：

CSB-EL004862HU
规格：

96T/48T
价格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

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产品描述：

人T复合物蛋白1亚基ε(CCT5)酶联免疫试剂盒（CSB-EL004862HU）为双抗夹心法ELISA试剂盒，定量检测血清、血浆,组织匀浆、细胞裂解物样本中的CCT5含量。CCT5是一种重要靶点。它属于分子伴侣蛋白家族，在细胞内参与众多蛋白质的折叠过程。目前研究关注其在细胞内稳态维持和疾病发生发展中的作用机制，了解其与疾病的关联，有望为相关疾病的治疗提供新的靶点和策略。试剂盒检测范围为15.6 pg/mL-1000 pg/mL，适用于体外培养细胞模型、动物组织或液体样本中CCT5表达水平的动态监测，为探索其在细胞增殖、凋亡调控或疾病模型中的功能提供定量分析工具，广泛用于分子生物学、病理机制及药物干预效果评估等基础研究领域。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
别名：

CCT 5 ELISA Kit; CCT epsilon ELISA Kit; CCT-epsilon ELISA Kit; CCT5 ELISA Kit; CCTE ELISA Kit; CCTepsilon ELISA Kit; Chaperonin containing T-complex polypeptide 1; subunit 5 ELISA Kit; Chaperonin containing TCP 1 epsilon ELISA Kit; Chaperonin containing TCP 1 subunit 5 ELISA Kit; Chaperonin containing TCP 1 subunit 5 epsilon ELISA Kit; Chaperonin containing TCP1 epsilon ELISA Kit; Chaperonin containing TCP1 subunit 5 ELISA Kit; Chaperonin containing TCP1 subunit 5 epsilon ELISA Kit; KIAA0098 ELISA Kit; T complex protein 1 epsilon subunit ELISA Kit; T complex protein 1 subunit epsilon ELISA Kit; T-complex protein 1 subunit epsilon ELISA Kit; TCP 1 epsilon ELISA Kit; TCP-1-epsilon ELISA Kit; TCP1epsilon ELISA Kit; TCPE ELISA Kit; TCPE_HUMAN ELISA Kit
缩写：

CCT5
Uniprot No.：

P48643
种属：

Homo sapiens (Human)
样本类型：

serum, plasma,tissue homogenates, cell lysates
检测范围：

15.6 pg/mL-1000 pg/mL
灵敏度：

3.9 pg/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Signal Transduction
测定原理：

quantitative
测定方法：

Sandwich
数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

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功能：

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
基因功能参考文献：
1. CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex PMID: 25995452
2. H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5. PMID: 25124038
3. introduction of the truncated human CCT epsilon subunit into yeast cells PMID: 22232265
4. A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia. PMID: 16399879
相关疾病：

Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP)
亚细胞定位：

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

TCP-1 chaperonin family
数据库链接：

HGNC: 1618

OMIM: 256840

KEGG: hsa:22948

STRING: 9606.ENSP00000280326

UniGene: Hs.1600

Human T-complex protein 1 subunit epsilon(CCT5) ELISA kit

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