Human Serum amyloid A-4 protein(SAA4) ELISA kit

Human Serum amyloid A-4 protein(SAA4) ELISA kit

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中文名称：

人血清淀粉样蛋白A4(SAA4)酶联免疫试剂盒
货号：

CSB-EL020659HU
规格：

96T/48T
价格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

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CUSABIO人血清淀粉样蛋白A4（SAA4）酶联免疫检测试剂盒（货号：CSB-EL020659HU），基于双抗体夹心法原理实现定量检测，适用于血清、血浆及组织匀浆样本中SAA4蛋白的精准分析。SAA4是急性期反应蛋白家族成员，在炎症调控、脂质代谢及淀粉样纤维形成中发挥重要作用，其表达水平与心血管疾病、慢性炎症及淀粉样变性等病理过程密切相关。该试剂盒检测灵敏度覆盖15.6 ng/ml至1000 ng/ml的浓度范围，通过预包被高特异性捕获抗体与标记检测抗体的协同作用，确保对目标蛋白的高效识别与信号放大。实验操作兼容常规ELISA流程，标准品提供7个浓度梯度，配套试剂包含样本稀释液、洗液及终止液，开盖即用。该产品适用于基础医学研究中SAA4蛋白的表达动态分析、疾病动物模型验证及炎症相关分子机制探索，可为生物标志物筛选、病理机制解析及药物干预效果评估提供可靠数据支持，严格限用于科研领域。
别名：

Amyloid A; serum; 4 ELISA Kit; C SAA ELISA Kit; C-SAA ELISA Kit; Constitutively expressed serum amyloid A protein ELISA Kit; CSAA ELISA Kit; SAA 4 ELISA Kit; Saa4 ELISA Kit; SAA4 protein ELISA Kit; SAA4_HUMAN ELISA Kit; Serum amyloid A 4 protein ELISA Kit; Serum amyloid A-4 protein ELISA Kit; Serum amyloid A4 constitutive ELISA Kit
缩写：

SAA4
Uniprot No.：

P35542
种属：

Homo sapiens (Human)
样本类型：

serum, plasma, tissue homogenates
检测范围：

15.6 ng/ml-1000 ng/ml.
灵敏度：

3.9 ng/ml.
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Cardiovascular
测定原理：

quantitative
测定方法：

Sandwich

精密度：

线性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human SAA4 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

	Sample	Serum(n=4)
1:100	Average %	97
	Range %	93-101
1:200	Average %	100
	Range %	95-104
1:400	Average %	95
	Range %	89-99
1:800	Average %	99
	Range %	94-104

回收率：

标准曲线：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ng/ml

OD1

OD2

Average

Corrected

1000

2.845

2.765

2.805

2.702

500

2.147

2.089

2.118

2.015

250

1.422

1.437

1.430

1.327

125

0.730

0.712

0.721

0.618

62.5

0.394

0.376

0.385

0.282

31.2

0.237

0.242

0.240

0.137

15.6

0.153

0.147

0.150

0.047

0.101

0.105

0.103

数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

Multi-Omics Analysis Reveals Up-Regulation of APR Signaling, LXR/RXR and FXR/RXR Activation Pathways in Holstein Dairy Cows Exposed to High-Altitude Hypoxia Kong Z, et al,Animals,2019

最新研究进展：

SAA4（serum amyloid A4）是SAA蛋白家族的一员，参与机体的免疫调节和炎症反应。最新研究表明，SAA4在某些肿瘤中表达升高，与肿瘤的发生和进展密切相关。此外，SAA4也参与了许多炎症和自身免疫疾病的发生和发展，成为新型治疗策略的热点研究对象。
功能：

Major acute phase reactant.
基因功能参考文献：
1. Data identified SAA4 as a protein that was positively correlated with RF and RA. SAA4 may represent a novel prescreening marker for the diagnosis of RA. PMID: 28505104
2. expressed in invasive trophoblast cells PMID: 24951172
3. Six apolipoproteins (APOA1, APOA2, APOB, APOC2, APOC3, and APOE) were able to differentiate bladder cancer from hernia. SAA4 was significantly increased in bladder cancer subgroups, whereas ProEGF was significantly decreased in bladder cancer subgroups. PMID: 23631828
4. studies provide the first evidence for a novel type of AA amyloidosis in which the fibrils were formed from a mutated SAA4 protein PMID: 20536400
5. The sequences of 1478 and 1836 bp of the SAA1 and SAA4 5'-flanking regions were determined. PMID: 12410800
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亚细胞定位：

Secreted.
蛋白家族：

SAA family
组织特异性：

Expressed by the liver; secreted in plasma.
数据库链接：

HGNC: 10516

OMIM: 104752

KEGG: hsa:6291

STRING: 9606.ENSP00000278222

UniGene: Hs.1955

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.