Human Renalase/ Monoamine Oxidase-C(RNLS/ MAO-C)ELISA Kit

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

1. Data (including data from studies in knockout mice) suggest that renalase functions as a protective plasma protein that reduces pancreatic acinar cell injury and prevents pancreatitis via interactions with plasma membrane calcium ATPase PMCA4b. PMID: 29042438
2. renalase may reduce renal tubular injury and apoptosis of renal tubular epithelial cells. PMID: 30074185
3. Urinary renalase concentration is reduced in the aftermath of coronary angiography/percutaneous coronary intervention, which may be related to contrast induced-acute kidney injury development. PMID: 27778420
4. we focus on the cytoprotective actions of renalase and its capacity to sustain cancer cell growth and also the translational opportunities these findings represent for the development of novel therapeutic strategies for organ injury and cancer PMID: 28238213
5. There is a high level of circulating renalase and advanced oxidation protein products in the heamodialysis patients. PMID: 28954489
6. Rs10887800 polymorphic variant of RNLS gene influences the level of circulating RNLS in patients undergoing hemodialysis, but not in healthy controls. PMID: 28372594
7. data suggest that renalase might play a role in hypertrophic response to pressure overload, but the exact mechanism requires further investigation PMID: 29065134
8. The development of preeclampsia in pregnant is accompanied by altered serum renalase levels. PMID: 27147460
9. High RNLS expression is associated with melanoma. PMID: 27197188
10. Renalase gene rs2296545 polymorphism is significantly associated with increased risk of hypertension(HT), whereas rs2576178 polymorphism may not be associated with the susceptibility to HT PMID: 27434211
11. The rs10887800 renalase gene polymorphism significantly increased the risk of coronary artery disease in hemodialyzed end-stage renal disease patients. PMID: 27023477
12. genetic association studies in a population of pregnant women in Pakistan: Data suggest that an SNP in renalase (rs10887800; but not rs2576178) is modestly associated with gestational diabetes mellitus in the population studied; no difference was observed in the serum levels of renalase in this case-control study. PMID: 27507673
13. analysis of metabolic function of renalase PMID: 27769837
14. Lack of the N-terminal peptide, the structural precondition for FAD binding, suggests that extracellular (circulating) renalase acts in a FAD-independent manner and mechanisms of its action are not associated with FAD. PMID: 27577995
15. Findings of the present study suggest that blood pressure may be increased by GG genotype and G allele of rs10887800 renalase polymorphism and the polymorphism may increase the susceptibility to preeclampsia. PMID: 27155338
16. plasma renalase was not significantly associated with hypertension and high brachial-ankle pulse wave velocity PMID: 27871085
17. Data show that nhibition of renalase caused tumor cell apoptosis and cell cycle arrest. PMID: 26972355
18. marked increase of glomerular renalase and its association with macrophages suggest that it might play an important role in disease progression of LN PMID: 26431044
19. Studies indicate definitive links between renalase catecholamine consumption and physiological responses. PMID: 25900362
20. the antihypertensive effect of renalase still remains a phenomenon with unclear biochemical mechanim(s) and functions of intracellular and extracellular (circulating) renalases obviously differ. PMID: 26716738
21. Single nucleotide polymorphisms in nNOS, renalase, MTHFR, CELSR1 and XYLB genes were found significantly associated with ischemic stroke in Chinese patients. PMID: 25855559
22. Serum levels of renalase are highly correlated with catecholamine and both serum renalase levels and renalase-catecholamine ratios are related to renal function PMID: 24590362
23. An association has been found between renalase (rs2296545) CC genotype and C allele and chronic kidney disease, along with significantly high serum epinephrine level. PMID: 25484193
24. Renalase levels were higher in heart transplant recipients compared with healthy volunteers. PMID: 25380930
25. This article demonstrates that renalase does not catalyze the oxidation of neurotransmitter catecholamines. PMID: 26049000
26. study is the first to present reference values of urine renalase excretion in a healthy pediatric population PMID: 25060760
27. the metabolic function of renalase is to oxidize isomeric NAD(P)H molecules to beta-NAD(P)(+). PMID: 25531177
28. Renalase gene rs2296545 polymorphism is not important factor determining renal allograft function. PMID: 24923329
29. The allele A of rs2576178 may be a predisposing factor of coronary heart disease in hypertensive patients, and hypertensive patients with AA genotype are susceptible to develop coronary heart disease. PMID: 24821235
30. Renalase transcript levels are associated with endogenous SP1, STAT3 and ZBP89 levels. PMID: 25295465
31. Our findings show that the polymorphism rs10887800 in the renalase gene is closely associated with severe intracranial cerebral atherosclerotic vascular stenosis in ischemic stroke patients of north Chinese Han origin. PMID: 24014100
32. Renalase promotes cell survival and protects against renal injury through the activation of intracellular signaling cascades, independent of its ability to metabolize catecholamines. PMID: 24511138
33. Elevated level of circulating renalase in dialysis patients is related to kidney function and the sympathetic nervous system hyperactivity found in this population. PMID: 23530612
34. Neither the oxidized nor the reduced form of renalase is able to catalyze anomerization, implying that the redox and anomerization chemistries are inextricably linked through a common intermediate. PMID: 24266457
35. SNPs rs10887800 & rs2576178 were significantly associated with ischemic stroke with hypertension. The recessive model showed a strong association of rs2296545 with ischemic stroke patients in hypertension subgroups. PMID: 23564542
36. Renalase may play a critical role in reproduction and hormone regulation. PMID: 23271136
37. A significant inverse correlation exists between serum renalase and residual kidney function. PMID: 22539018
38. Renalase is elevated among heart transplant recipients and is predominantly dependent on renal function PMID: 23375328
39. results are the first to suggest an association between renalase gene polymorphisms analysed and hypertension in dialysed patients. PMID: 21617193
40. genome-wide association studies in European ancestry groups: Data suggest that alleles conferring susceptibility to type 1 diabetes [renalase (RNLS; rs10509540) and interleukin-2 (IL-2; rs2069763)] are associated with lower age-at-diagnosis/onset). PMID: 22891215
41. Both before and after adjustment for sex, age and body mass index, the renalase polymorphisms did not show any effect on hypertension prevalence. PMID: 22812913
42. Studies in humans with resistant hypertension indicate that plasma renalase levels are inversely associated with systolic blood pressure--REVIEW PMID: 21424526
43. polymorphisms of the renalase gene in hemodialysed patients were associated with hypertension [review] PMID: 22227817
44. The renalase gene polymorphism was associated with hypertension in type 2 diabetes patients. The most interesting result was a strong association of the rs10887800 polymorphism with stroke in patients with and without diabetes. PMID: 21964580
45. Renalase, highly elevated in heart transplant recipients, is predominantly dependent on kidney function, which deteriorates with time after heart transplantation and age. PMID: 22172866
46. Renalase is highly elevated in kidney transplant recipients, predominantly dependent on kidney function, which deteriorates with time after kidney transplantation and age. PMID: 21996211
47. Renalase adopts the p-hydroxybenzoate hydroxylase fold topology, comprising a Rossmann-fold-based flavin adenine dinucleotide (FAD)-binding domain and a putative substrate-binding domain. PMID: 21699903
48. The two recombinant renalase forms displayed the same molecular properties. They bind equimolar amounts of FAD and appear to be correctly folded by various criteria. PMID: 20302943
49. Our identification of renalase, a soluble monoamine oxidase in the brain, highlights the possible existence of other pathways regulating monoamine neurotransmitter levels in the CNS. PMID: 20168325
50. secreted by the kidney, circulates in blood, and modulates cardiac function and systemic blood pressure PMID: 15841207

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Secreted.

Renalase family

Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy

HGNC: 25641

OMIM: 609360

KEGG: hsa:55328

UniGene: Hs.149849