Human Protamine 1,PRM1 ELISA Kit

1. The expression level of PRM1 was significantly higher in colon cancer tissues and the staining degree of PRM1 in poorly-differentiated was stronger. PMID: 29140788
2. Bacterial infections have significant negative effects on sperm chromatin condensation and protamine P1/P2 ratio. PMID: 28736810
3. Protamine-1 and protamine-2 mRNA levels as well as the protamine mRNA ratio and all routine semen parameters revealed significant differences between recurrent miscarriage couples and healthy volunteers. Values of protamine-1 and protamine-2 mRNAs were significantly higher and the protamine mRNA ratio was significantly lower in couples with recurrent miscarriage. PMID: 28854581
4. examinded the association between protamine gene alleles (PRM1 c.-190C>A, PRM1 c.197G>T, and PRM2 c.248C>T), and YBX2 (c.187T>C and c.1095 + 16A>G) and male infertility. We found that the AA and CA genotypes of the PRM1 c.-190C>A polymorphism had a significant association with infertility (p < 0.001) and the AA genotype was also highly significantly associated with high sperm DNA damage (p < 0.001). PMID: 29227750
5. The KDM3A to PRM1 mRNA expression ratio can be used as a reliable marker of successful testicular sperm extraction in men with obstructive and non-obstructive azoospermia with 95% sensitivity. PMID: 27027467
6. Single nucleotide polymorphisms in the human PRM1 gene are associated with a genetic risk factor for idiopathic oligozoospermia. PMID: 27216534
7. Studies indicate that ribonucleotide reductase M1 polypeptide (RRM1) expression is associated with the response rate and overall survival rate of advanced NSCLC patients treated with gemcitabine-based chemotherapy. PMID: 26092210
8. The expressed human protamine1 in two fast-growing cell systems, E. coli and HeLa cells. The protamine 1 expression significantly attenuated cell proliferation when compared with control cells. PMID: 25649960
9. the quantity of PRM1, PRM2, and TNP2 transcripts and the PRM1/PRM2 mRNA ratio affect spermiogenesis, sperm morphology PMID: 25536093
10. Single nuclotide polymorphisms in PRM1 gene is associated with male infertility. PMID: 22104739
11. genetic association study in Han population in China: Data suggest that an SNP in PRM1 (rs35576928; T allele; 34R>S) is associated with severe oligozoospermia and can play a protective role against this disease. PMID: 23079002
12. The SNP of PRM1-190C- > A might be associated with teratozoospermia-induced male infertility in the Han Chinese. PMID: 22574365
13. significant correlation has been found between protamine 1 and 2 transcripts/proteins and: sperm concentration, progressive sperm motility, sperm fertilization ability as well as embryo quality PMID: 22472940
14. identified and we report for the first time five novel rare haplotypes encompassing the protamine 1 and 2 genes PMID: 21029114
15. Data suggest that Casp4, Casp 6 and TNFSF10 are differentially expressed in potentially fertile and subfertile men and represent useful biomarkers for predicting male fertility in combination with P1 and P2. PMID: 21317160
16. Mutations in the protamine locus may be an infrequent cause of male infertility. PMID: 19602509
17. single nucleotide polymorphisms in this gene in fertile and infertile males PMID: 12569175
18. A number of SNPs are present in the testis-specific nuclear protein genes. PMID: 16989827
19. The P1/P2 ratio has a significant relationship to sperm fertilization ability. PMID: 17011555
20. Mutations in PRM1 gene were identified in males with oligozoospermia. PMID: 17494104
21. The PRM1 contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos. PMID: 18292840
22. A reduction in contents of PRM1 transcript in spermatozoa may be linked with asthenozoospermia. PMID: 18292846
23. Decreased pre-P2/P2 and P1/P2 ratios are related to a poor pregnancy outcome, but not with the proportion of embryos obtained after assisted reproduction. PMID: 18314125
24. Low-frequency protamine 1 gene transversions c.102G->T and c.-107G->C do not correlate with male infertility. PMID: 18381856
25. Histones localized to the posterior ring region (i.e. the sperm nuclear annulus), whereas PRM1 and PRM2 appeared to be dispersed throughout the entire nucleus. PMID: 18478156
26. The CCNA1, CCNB1, CCNB2, PRM1, and PRM2 messenger RNA transcript ratios were significantly decreased in patients with spermatogenic disorders. Transcript ratios in patients with successful sperm retrieval were higher than with failed sperm retrieval. PMID: 18692784

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HGNC: 9447

OMIM: 182880

KEGG: hsa:5619

STRING: 9606.ENSP00000310515

UniGene: Hs.2909