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中文名称：人妊娠特异性β1糖蛋白(SP1/PSβ1-G)酶联免疫试剂盒
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货号：CSB-E09133h
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规格：96T/48T
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价格：￥3600/￥2500
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其他：
产品详情
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产品描述：人妊娠特异性β1糖蛋白(SP1/PSβ1-G)酶联免疫试剂盒（CSB-E09133h）为竞争法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的SP1/PSβ1-G含量。人妊娠特异性β1糖蛋白（SP1/PSβ1-G）是由胎盘合体滋养层细胞合成的特异性糖蛋白，具有免疫调节、抗炎和促血管生成作用。其结构/功能关系研究显示，SP1可以与多种调节蛋白协同作用，通过保守的短线性基序参与蛋白质-蛋白质相互作用，对药物设计和疾病诊断具有重要意义。试剂盒检测范围为1.0 μg/mL-400 μg/mL，适用于科研领域中对妊娠期母体血清或胎盘组织匀浆中SP1水平的动态监测，可应用于探究妊娠高血压、胎儿生长受限等病理状态下胎盘功能异常的分子机制，或用于评估体外模型中滋养层细胞分泌蛋白的功能研究。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
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别名：B1G1 ELISA Kit; Carcinoembryonic antigen SG8 ELISA Kit; CD66 antigen-like family member F ELISA Kit; CD66f ELISA Kit; CD66f antigen ELISA Kit; CEA ELISA Kit; DHFRP2 ELISA Kit; Fetal liver non-specific cross-reactive antigen 1/2 ELISA Kit; FL-NCA-1/2 ELISA Kit; PBG 1 ELISA Kit; PBG1 ELISA Kit; Pregnancy specific B 1 glycoprotein ELISA Kit; Pregnancy specific beta 1 glycoprotein 1 ELISA Kit; Pregnancy specific beta 1 glycoprotein 2 ELISA Kit; Pregnancy specific beta 1 glycoprotein 7 ELISA Kit; Pregnancy specific beta 1 glycoprotein 8 ELISA Kit; Pregnancy specific beta 1 glycoprotein ELISA Kit; Pregnancy specific beta 1 glycoprotein C/D ELISA Kit; Pregnancy-specific beta-1 glycoprotein C/D ELISA Kit; Pregnancy-specific beta-1-glycoprotein 1 ELISA Kit; Pregnancy-specific glycoprotein 1 ELISA Kit; PS beta C/D ELISA Kit; PS-beta-C/D ELISA Kit; PS-beta-G-1 ELISA Kit; PSBG 1 ELISA Kit; PSBG 2 ELISA Kit; PSBG-1 ELISA Kit; PSBG1 ELISA Kit; PSBG2 ELISA Kit; PSG 1 ELISA Kit; PSG 2 ELISA Kit; PSG 8 ELISA Kit; PSG 95 ELISA Kit; PSG IIA d ELISA Kit; PSG1 ELISA Kit; PSG1_HUMAN ELISA Kit; PSG2 ELISA Kit; PSG8 ELISA Kit; PSG95 ELISA Kit; PSGGA ELISA Kit; PSGGB ELISA Kit; PSGIIA a ELISA Kit; PSGIIA ELISA Kit; PSGIIA b ELISA Kit; PSGIIA c ELISA Kit; SP 1 ELISA Kit; SP1 ELISA Kit
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缩写：SP1/PSβ1-G
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Uniprot No.：
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种属：Homo sapiens (Human)
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样本类型：serum, plasma, tissue homogenates
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检测范围：1.0 μg/mL-400 μg/mL
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灵敏度：1.0 μg/mL
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Tags & Cell Markers
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测定原理：quantitative
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测定方法：Competitive
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精密度：
Intra-assay Precision (Precision within an assay): CV%<15% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<15% Three samples of known concentration were tested in twenty assays to assess. -
线性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human SP1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 96 Range % 89-106 1:2 Average % 90 Range % 89-104 1:4 Average % 95 Range % 88-100 1:8 Average % 87 Range % 82-99 -
回收率：
The recovery of human SP1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 95 86-107 EDTA plasma (n=4) 97 91-100 -
标准曲线：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
μg/ml OD1 OD2 Average 400 0.139 0.144 0.142 75 0.269 0.278 0.274 12.5 0.534 0.556 0.545 3.5 0.853 0.873 0.863 1 1.452 1.464 1.458 0 2.137 2.161 2.149 -
数据处理：
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货期：3-5 working days
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基因功能参考文献：
- Inhibiting PSG1 can effectively reduce chemoresistance via a transforming growth factor-beta (TGF-beta)-related pathway in ER-negative breast cancer cells. PMID: 27653744
- PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-gamma. PMID: 27595833
- Under conditions of directed induction of phenotypic changes in CD4(+) lymphocytes to regulatory T cells (Treg), pregnancy-specific at high concentrations (10 and 100 mug/mL) increased FOXP3 expression. The evaluation of the spontaneous expression level of FOXP3 mRNA showed that pregnancy-specific beta1-glycoprotein (1 and 100 mug/mL) stimulated the expression of this factor in mononuclear cells and isolated CD4(+) lym... PMID: 27817017
- results identify a non-placental site of PSG expression in the gut and associated tumors, with implications for determining whether PSGs have a role in tumor progression, and utility as tumor biomarkers. PMID: 26926266
- the presence of GAGs on the surface of endothelial cells was required for the ability of PSG1 to induce tube formation PMID: 21193412
- The aspartic acid at position 95 is not required for PSG1 activity but the amino acids implicated in the formation of a salt bridge within the N-domain are essential. PMID: 20335639
- first trimester maternal serum marker of small-for-gestational age and preterm delivery PMID: 19911417
- Human PSG1a induces alternative activation in human & mouse monocytes & suppresses the accessory-cell-dependent T-cell proliferation. PSG1a contributes to immunomodulation during pregnancy, with opposite effects on maternal innate & adaptative systems. PMID: 12223519
- The differential expression of HLA-E and PSG1 in the sperm of fertile and infertile men is discussed. PMID: 18987160
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亚细胞定位：Secreted.
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蛋白家族：Immunoglobulin superfamily, CEA family
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数据库链接：
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