Human Oligodendrocyte-myelin glycoprotein(OMG) ELISA kit

产品详情

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.

产品描述：

人少突细胞髓磷脂糖蛋白(OMG)酶联免疫试剂盒（CSB-EL016334HU）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的OMG含量。试剂盒检测范围为0.156 ng/mL-10 ng/mL，适用于神经科学基础研究，如多发性硬化症、脑白质营养不良等疾病模型的分子机制探索，亦可应用于药物开发中髓鞘修复相关化合物的体外效果评价。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
别名：

Oligodendrocyte-myelin glycoprotein ELISA Kit; Omg ELISA Kit; OMGP ELISA Kit; OMGP_HUMAN ELISA Kit
缩写：

OMG
Uniprot No.：

P23515
种属：

Homo sapiens (Human)
样本类型：

serum, plasma, tissue homogenates
检测范围：

0.156 ng/mL-10 ng/mL
灵敏度：

0.039 ng/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Neuroscience
测定原理：

quantitative
测定方法：

Sandwich

精密度：

线性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human OMG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	85
	Range %	80-89
1:2	Average %	97
	Range %	92-102
1:4	Average %	92
	Range %	87-98
1:8	Average %	98
	Range %	94-102

回收率：

The recovery of human OMG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	88	84-92
EDTA plasma (n=4)	107	102-112

标准曲线：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

METHODS FOR DIFFERENTIATING ISCHEMIC STROKE FROM HEMORRHAGIC STROKE Montaner Viallonga, Joan.et al,United States Patent Application ,2017

功能：

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.
基因功能参考文献：
1. The results do not support a relationship between the OMGP gene and the learning disability phenotype observed in neurofibromatosis type 1. PMID: 21534343
2. novel mutations and novel polymorphisms in coding regions and 5'UTR were detected in patients with with non-syndromic mental retardation PMID: 16425041
3. Data show that oligodendrocyte-myelin glycoprotein is downregulated in schizophrenia anterior temporal lobe revealed by shotgun proteome analysis. PMID: 19034380
亚细胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
组织特异性：

Oligodendrocytes and myelin of the central nervous system.
数据库链接：

HGNC: 8135

OMIM: 164345

KEGG: hsa:4974

STRING: 9606.ENSP00000247271

UniGene: Hs.113874