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中文名称：人基质金属蛋白酶-21(MMP21)酶联免疫试剂盒
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货号：CSB-EL014668HU
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规格：96T/48T
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价格：￥3600/￥2500
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其他：
产品详情
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产品描述：人基质金属蛋白酶-21(MMP21)酶联免疫试剂盒（CSB-EL014668HU）为双抗夹心法ELISA试剂盒，定量检测血清、血浆,组织匀浆样本中的MMP21含量。MMP21 即基质金属蛋白酶 21，在胚胎发育、细胞迁移等生理过程有重要作用。其研究机制主要聚焦在酶活性调控、与底物相互作用方面。它的异常表达与肿瘤侵袭、转移等病理过程相关，深入研究有助于为相关疾病治疗提供新靶点。试剂盒检测范围为1.56 ng/mL-100 ng/mL，标准化流程适用于基础研究中对MMP21表达水平的动态监测，例如在细胞功能研究、疾病模型构建或药物干预实验中评估该蛋白的生物学作用，为探索其在炎症性疾病、纤维化或肿瘤进展中的机制提供数据支持。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
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别名：MMP21Matrix metalloproteinase-21 ELISA Kit; MMP-21 ELISA Kit; EC 3.4.24.- ELISA Kit
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缩写：MMP21
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Uniprot No.：
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种属：Homo sapiens (Human)
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样本类型：serum, plasma,tissue homogenates
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检测范围：1.56 ng/mL-100 ng/mL
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灵敏度：0.39 ng/mL
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Cancer
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测定原理：quantitative
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测定方法：Sandwich
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数据处理：
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货期：3-5 working days
引用文献
- ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21 Y Xiang,Cancer Cell International,2020
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靶点详情
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功能：Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin.
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基因功能参考文献：
- MMP-21 572TT genotype increased the risk for the HIV-associated neurocognitive disorder. PMID: 29575199
- loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. PMID: 26429889
- Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance. PMID: 26437028
- Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and lymph node metastasis. PMID: 25015395
- These results suggest that high MMP-21 expression in lymph node metastatic foci can be used to predict survival in OSCC patients with LNM PMID: 24700287
- analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients PMID: 23275114
- MMP-21 expression is elevated in primary CRC and related to tumor invasion and metastasis. MMP-21 was also proved to be an independent prognostic factor for patients with stage II and stage III colorectal cancer. PMID: 21656525
- MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation. PMID: 19601983
- MMP-21 was expressed by Merkel cell carcinoma cells in 13/43 cases and in eight samples by stromal neutrophils. None of the samples with MMP-21-expressing neutrophils had metastasized to the lymph nodes PMID: 19921252
- The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer. PMID: 15015597
- MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer PMID: 17873896
- MMP-21 may be an important protease in the terminal differentiation of keratinocytes PMID: 18633436
- A nonsynchronous polymorphism in the MMP-21 promoter does not significantly confer susceptibility to hepatocellular carcinoma in a southern Chinese population. PMID: 18768525
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相关疾病：Heterotaxy, visceral, 7, autosomal (HTX7)
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亚细胞定位：Secreted.
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蛋白家族：Peptidase M10A family
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组织特异性：Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
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数据库链接：
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