Human Interleukin 29(IL-29)ELISA Kit

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

1. SOCS2 impairs IFN/JAK/STAT signaling through reducing the stability of tyrosine kinase 2 (TYK2), downregulating the expression of type I and III IFN receptors, attenuating the phosphorylation and nucleus translocation of STAT1. PMID: 28496097
2. In conclusion, IL-29 enhanced CXCL10 production in human oral epithelial cells via the p38 MAPK, STAT3, and NF-kappaB pathways, which might control Th1-cell accumulation in periodontal lesions and be involved in pathological processes in periodontal disease. PMID: 28753407
3. The DNA binding domain of Ku70 was essential for formation of the Ku70-STING complex. Knocking down STING in primary human macrophages inhibited their ability to produce IFN-lambda1 in response to transfection with DNA or infection with the DNA virus HSV-2 (herpes simplex virus-2). Together, these data suggest that STING mediates the Ku70-mediated IFN-lambda1 innate immune response to exogenous DNA or DNA virus infection. PMID: 28720717
4. The review focuses on the value of the type I and III interferon subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses). PMID: 27544015
5. Interferon lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation. PMID: 28678391
6. IFN-lambda1 may play an important role in anti-respiratory syncytial virus infection. PMID: 28606236
7. Ebola virus VP24, in addition of inhibiting IFN-induced antiviral responses, was found to efficiently inhibit type III IFN-lambda1 gene expression. PMID: 28595092
8. STAT2 recruits USP18 to the type I IFN receptor subunit IFNAR2 via its constitutive membrane-distal STAT2-binding site. PMID: 28165510
9. IFN-lambda1 is likely to play a role in the pathogenesis of CSU. Blocking IFN-lambda1 production may help to reduce the accumulation of inflammatory cells in the involved CSU skin. PMID: 27445435
10. IL-29 stimulates inflammation and cartilage degradation by OA FLS, indicating that this cytokine is likely involved in the pathogenesis of OA. PMID: 27433031
11. IL-29 is a potential biomarker for disease activity in anti-cyclic citrullinated peptide-antibodies positive rheumatoid arthritis patients. PMID: 28154345
12. this study shows that serum levels of IL-29 play a role in the pathogenesis of Hashimoto's thyroiditis in Turkey PMID: 27617784
13. serum levels of IL-32 and TNF-alpha may be diagnostic markers, and serum IL-29 levels may be associated with good prognosis in patients with gastric cancer PMID: 26219901
14. Serum levels of IL-29 and IFN-gamma are predictive of relapse outcomes after hepatitis C treatment. PMID: 26342113
15. IL-29 selectively induces CXCR3A-binding chemokines (CXCL9, CXCL10, CXCL11) in skin cells. Murine IL-29 counterpart induces skin T-cell infiltration and inflammation in mice. PMID: 26612594
16. activation of TLR7 upregulated the expression levels of IFN-lambda1 and MMP-9 were increased by ~3 fold, whereas other genes (p53, PTEN, TIMP-1) were upregulated by ~2 fold, and VEGF was marginally upregulated after 10 min. PMID: 26718740
17. IL-29 directly induces RANKL expression in rheumatoid arthritis-fibroblasts like synoviocytes via MAPK signaling pathway. PMID: 26420479
18. showed that silencing IFN-lambda1 in T/T cell line reduced basal IFN-stimulated gene expression and improved antiviral activity PMID: 26896692
19. IFN-lambda-1 and interferon-gamma levels in systemic sclerosis patients were significantly higher than those in healthy individuals. PMID: 26057401
20. this study failed to prove any significant association between polymorphisms in IL29 gene rs30461 or IL10 gene (-1082, -819 and -592) or cytokine haplotype and either response to therapy or severity of HCV infection in children. PMID: 25936570
21. IL-29 can aggravate LPS/TLR4-mediated inflammation. PMID: 26278073
22. NS of severe fever with thrombocytopenia syndrome virus inhibited the activity of IFN-alpha1, IFN-beta, IFN-lambda1 and IFN-lambda2 through inhibition of STAT1 phosphorylation. PMID: 26353965
23. the role of IFN-lambda in IDO regulation was investigated after influenza infection of respiratory epithelial cells. PMID: 25756191
24. Data suggest that naturally occurring iDVGs (immunostimulatory defective viral genomes) trigger robust host antiviral/innate immunity responses including/requiring up-regulation of IFNL1 and IFNB1 (interferon beta 1) in respiratory mucosa. PMID: 26336095
25. there seems to be an inverse link between IFN-lambda and the severity of allergic asthma and allergic asthma exacerbations. PMID: 25592858
26. Studies indicate that the type III interferons (IFNs) or IFN-lambdas consists of four members: IFN-lambda1 (IL-29), IFN-lambda2 (IL28A), IFN-lambda3 (IL-28B) and IFN-lambda4. PMID: 26194286
27. Increased quantity of IL-29 in GCF and plasma of subjects with periodontitis suggests a role in pathogenesis of periodontitis and the SNP (rs30461) is not related to susceptibility to periodontitis in this population of Indian individuals. PMID: 25255471
28. Severity of rhinovirus-induced asthma symptoms is inversely related to resolution IFNL1 expression. PMID: 25784275
29. IL-29 is dysregulated in patients with rheumatoid arthritis (RA), which may contribute to the RA pathogenesis via inducing the production of proinflammatory cytokines, chemokines or matrix metalloproteinases in synovial fibroblasts. PMID: 23078630
30. intranasal delivery of adenovirus expressing protein suppresses allergic asthma in a murine model PMID: 24819718
31. IFN-lambda1-mediated IL-12 production in macrophages induces IFN-gamma production in human NK cells. PMID: 25316442
32. data suggest that the p38alpha MAPK pathway is linked with RLR signaling pathways and regulates the expression of early IFN genes after RNA stimulation cooperatively with IRF3 and NF-kappaB to induce antiviral responses further PMID: 25473098
33. Interferon lambda 1 induces antiviral response to herpes simplex virus 1 infection. PMID: 25518713
34. These results show that type III interferons (IFN-lambdas) play a critical protective role in human metapneumovirus infection. PMID: 25355870
35. Results showed no association between genotypes and alleles of IL28A, IL28B or IL29 polymorphisms and Hepatitis C virus infection. PMID: 24269996
36. This study is the first to show the activation of a type III interferon response in low-risk human papillomavirus positive cervical cells and suggests that the lack of this response may be related to lesion progression. PMID: 24510368
37. our data suggest that human but not mouse hepatocytes are responsive to IFN-lambda in vivo. PMID: 24498220
38. protein expression is inhibited by hepatitis C virus PMID: 23529855
39. IFNL1 expression in the human colon is transcriptionally regulated by ZEB-1, BLIMP-1, and NF-kappaB p50 and p65. PMID: 24140069
40. These data suggest that T(Helper)17 cell-derived IL-29, which is absent in atopic dermatitis, mediates the robust antiviral state on psoriatic skin, and demonstrate a new function of T(H)17 cells. PMID: 24068736
41. HBV infection upregulates IL-27 expression, which, in turn, stimulates IFN-lambda1 production. PMID: 24337382
42. Interferon regulatory factor (IRF)-3 and -7 are the key transcriptional factors for the induction of IL-28A and IL-28B genes, whereas NF-kappaB is an additional requirement for the induction of the IL-29 gene. PMID: 24385435
43. IL-32 levels during viral infection mediate antiviral effects by stimulating the expression of IFN-lambda1. PMID: 23729669
44. IFN-lambdas can also directly affect T cells through inhibition of the T helper 2 cell (Th2) responses. IFN-lambdas have varying immunomodulatory functions under different physiological conditions PMID: 23207147
45. RA patients that presented knee joint involvement displayed higher serum IFN-lambda1 than patients without knee joint involvement, suggesting that abnormally elevated IFN-lambda1 levels in RA can associate with knee joint disease. PMID: 23039206
46. The viral infection induced both IFN-lambda1 promoter activity and that of the 3'-untranslated region (UTR), indicating that IFN-lambda1 expression is also regulated at the post-transcriptional level. PMID: 23150165
47. IL-29 can regulate expression of protease activated receptors and tryptase- and trypsin-induced IL-4 production in mast cells. PMID: 23218741
48. These data support a model of coordinated cell- and ligand-specific expression of types I and III interferon. PMID: 22249201
49. After non-surgical periodontal therapy, IL-29 levels increased both in chronic and aggressive periodontitis patients. PMID: 23151616
50. IFN-alpha and IFN-lambda signal through distinct receptors, they induce expression of a common set of ISGs in hepatocytes. However, unlike IFN-alpha, IFN-lambda1 did not induce STAT activation or ISG expression by purified lymphocytes or monocytes PMID: 23258595

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Secreted.

Lambda interferon family

HGNC: 18363

OMIM: 607403

KEGG: hsa:282618

STRING: 9606.ENSP00000329991

UniGene: Hs.406745