Human Interferon alpha-inducible protein 27, mitochondrial(IFI27) ELISA kit

Probable adapter protein involved in different biological processes. Part of the signaling pathways that lead to apoptosis. Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. Also functions in TNFSF10-induced apoptosis. May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. May thereby play a role in the vascular response to injury. In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV. May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A.

1. High IFI27 expression is associated with invasion in oral squamous cell carcinoma. PMID: 29580248
2. NEAT1 and the coding gene IFI27 were highly co-expressed and negatively correlated with dengue severity. Monitoring NEAT1and IFI27 expression in PBMC may be useful in understanding dengue virus-induced disease progression. PMID: 29031635
3. IFI27 was expressed in Influenza patients but not in Bacterial Respiratory Infection. IFI27 displayed 88% diagnostic accuracy (AUC) and 90% specificity in discriminating between Influenza and Bacterial Infections. PMID: 28619954
4. ISG12a inhibited HCV replication and potentiated the anti-HCV activity of IFN-alpha possibly through induced production of type I IFNs and activation of Jak/STAT signaling pathway independent of autophagy and cell apoptosis. PMID: 27777077
5. the ISG12 family of proteins has an important role for the apoptotic properties induced by type 1 interferon. PMID: 27673746
6. IFI27 mRNA level is reduced in peripheral blood mononuclear cells of immunoglobulin A nephropathy and membranous nephropathy patients. PMID: 27100186
7. IFI27 is involved in proliferation of skin keratinocytes both in vitro and in vivo. PMID: 25664647
8. Data indicate that AKT control TRAIL resistance of cancer cells through downregulation of interferon stimulated gene 12a (ISG12a) by MicroRNA-942 (miR-942). PMID: 24970806
9. We found that IFI27 is overexpressed in ovarian cancer and associated with patients' survival. PMID: 25103640
10. MiR-942 regulates hepatitis c virus-induced apoptosis of human hepatocytes by targeting ISG12a. PMID: 24727952
11. These results suggest that high basal ISG12a may inhibit Newcastle disease virus replication and oncolysis, while low basal ISG12a may allow sufficient Newcastle disease virus replication for induction of ISG12a. PMID: 24999841
12. Alterations in mechanisms associated with immune response and mitochondrial function that explain the up-regulation of IFI27 may provide an understanding of the pathways related to the intensification of fatigue during localized radiation therapy. PMID: 23959120
13. After inhibiting the autophagy, the expression of interferon b1 and IFI27 were decreased. PMID: 23383510
14. Patients with atypical teratoid/rhabdoid tumors show high p27 expression when angiogenesis and density of newly formed blood vessels were investigated. PMID: 22309998
15. interferon alpha-inducible protein 27 (IFI27) transcription stimulation was weaker in leiomyoma than myometrial cells PMID: 22320196
16. IFI27 may be a novel biomarker of disease activity and tumor burden in patients with chronic myeloproliferative neoplasms PMID: 21447007
17. We identify IFI27, CCL2 and CXCL10 as sensitive biomarkers for the response of multiple sclerosis patients to IFN-beta. PMID: 19558503
18. Assessment of p21, p27, Bax, and cyclin E expression in tumor tissues have been reported to be useful as prognostic factors in head and neck squamous cell carcinoma. PMID: 14719078
19. Upregulated in whole blood of infants hospitalised with respiratory syncytial virus (RSV), subtype B, bronchiolitis. PMID: 17166282
20. REsults describe the differential regulation of the interferon induced gene ISG12A by serum from healthy and preeclamptic pregnancies. PMID: 18329281
21. data suggest that ISG12a contributes to IFN-dependent perturbation of normal mitochondrial function, thus adding ISG12a to a growing list of IFN-induced proteins that impact cellular apoptosis. PMID: 18330707
22. five genes (TNFSF10/TRAIL, IL1RN, IFI27, GZMB, and CCR5) were upregulated and three genes (CLK1, TNFAIP3 and BTG1) were downregulated in at least three out of four subpopulations during acute GVHD. PMID: 18814951

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Mitochondrion membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

IFI6/IFI27 family

HGNC: 5397

OMIM: 600009

KEGG: hsa:3429

STRING: 9606.ENSP00000298902

UniGene: Hs.532634