Human Inter-alpha-trypsin inhibitor heavy chain H3(ITIH3) ELISA kit

Human Inter-alpha-trypsin inhibitor heavy chain H3(ITIH3) ELISA kit

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中文名称：

人间α胰蛋白酶抑制剂重链H3(ITIH3)酶联免疫试剂盒
货号：

CSB-EL011896HU
规格：

96T/48T
价格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

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产品描述：

人间α胰蛋白酶抑制剂重链H3(ITIH3)酶联免疫试剂盒（CSB-EL011896HU）为竞争法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的ITIH3含量。ITIH3是一种在血清中作为透明质酸载体的蛋白质，同时促进与各种基质蛋白的相互作用。这些相互作用调节透明质酸的定位、合成和降解，对多种细胞活动至关重要。ITIH3在生理和病理过程中发挥重要作用，如炎症、肿瘤发生、神经发育和精神疾病等。试剂盒检测范围为78.13 ng/mL-5000 ng/mL，该产品适用于基础医学研究中ITIH3蛋白表达水平分析，例如肝脏功能研究、炎症相关疾病模型构建、生物标志物筛选等领域，可为探索ITIH3在细胞黏附、组织修复中的分子机制提供可靠数据支持。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
别名：

ITIH3 ELISA Kit; Inter-alpha-trypsin inhibitor heavy chain H3 ELISA Kit; ITI heavy chain H3 ELISA Kit; ITI-HC3 ELISA Kit; Inter-alpha-inhibitor heavy chain 3 ELISA Kit; Serum-derived hyaluronan-associated protein ELISA Kit; SHAP ELISA Kit
缩写：

ITIH3
Uniprot No.：

Q06033
种属：

Homo sapiens (Human)
样本类型：

serum, plasma, tissue homogenates
检测范围：

78.13 ng/mL-5000 ng/mL
灵敏度：

19.53 pg/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Others
测定原理：

quantitative
测定方法：

Competitive

精密度：

线性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human TIH3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:20	Average %	92
	Range %	86-99
1:40	Average %	97
	Range %	92-103
1:80	Average %	86
	Range %	80-89
1:160	Average %	90
	Range %	83-99

回收率：

The recovery of human TIH3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	90	87-95
EDTA plasma (n=4)	95	90-100

标准曲线：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average
5000	0.083	0.085	0.084
2500	0.139	0.147	0.143
1250	0.223	0.220	0.222
625	0.329	0.347	0.338
312.5	0.572	0.614	0.593
156.3	0.814	0.849	0.832
78.13	1.228	1.259	1.244
0	2.081	2.226	2.154

数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis CB Schroeter,Acta neuropathologica,2024
Multi-Omics Analysis Reveals Up-Regulation of APR Signaling, LXR/RXR and FXR/RXR Activation Pathways in Holstein Dairy Cows Exposed to High-Altitude Hypoxia Kong Z, et al,Animals,2019

功能：

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
基因功能参考文献：
1. ITIH3 rs2535629 SNP was genotyped in N=256 patients receiving various antipsychotics for up to 26weeks. Study found no association of genotype with overall changes in Brief Psychiatric Rating Scale scores, but greater improvement of negative symptoms in minor allele carriers indicates that rs2535629 may help to identify a subset of schizophrenia patients with better treatment response to clozapine. PMID: 27396837
2. confirmed the association of schizophrenia with ITIH3/4 in a Han Chinese population PMID: 26206863
3. A novel association between suicide attempt and the ITIH3/4-region in a combined group of patients with bipolar disorder, schizophrenia and related psychosis spectrum disorders. PMID: 24461634
4. Study showed the association of a polymorphism (rs2535629) of ITIH3 with psychiatric disorders in an Asian population and that rs2535629 influences the susceptibility to psychiatric disorders by affecting the expression level of GLT8D1 PMID: 24373612
5. This study demonistrated that Genome-wide significant associations in schizophrenia to ITIH3/4 and extensive replication of associations reported by the Schizophrenia. PMID: 22614287
6. ITIH3 protein was found to be more highly expressed in plasma of tumor bearing mice compared to control. PMID: 20515073
7. ITIH3 single-nucleotide polymorphism is a novel genetic risk factor of myocardial infarction. PMID: 17211523
8. Widespread heavy chain 3 was only present in urinary stone formers PMID: 17898697
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亚细胞定位：

Secreted.
蛋白家族：

ITIH family
数据库链接：

HGNC: 6168

OMIM: 146650

KEGG: hsa:3699

STRING: 9606.ENSP00000415769

UniGene: Hs.76716

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.