Human Cross-linked Carboxy-terminal telopeptide of type Ⅰ collagen, CTX-I ELISA Kit

Human Cross-linked Carboxy-terminal telopeptide of type Ⅰ collagen, CTX-I ELISA Kit

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中文名称：

人Ⅰ型胶原交联羧基末端肽(CTX-I)酶联免疫试剂盒
货号：

CSB-E11224h
规格：

96T/48T
价格：

￥3200/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

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产品描述：

CUSABIO人Ⅰ型胶原交联羧基末端肽（CTX-I）酶联免疫检测试剂盒（货号：CSB-E11224h），基于双抗体夹心法原理设计，可对血清、血浆及组织匀浆样本中的CTX-I进行定量分析。CTX-I是骨吸收过程中释放的Ⅰ型胶原蛋白降解产物，其浓度变化可反映骨代谢动态平衡状态，常用于骨质疏松机制研究、骨关节疾病模型评估及抗骨吸收药物开发等科研领域。试剂盒检测灵敏度为0.625 ng/mL，线性范围覆盖0.625-40 ng/mL，通过预包被高特异性抗体实现精准捕获目标蛋白，结合优化反应体系确保检测重复性。实验操作兼容常规酶标仪进行吸光度读数，96孔板规格满足高通量检测需求，配套标准品与生物素化检测抗体可系统构建标准曲线，适用于体外骨代谢标志物检测、细胞模型骨吸收活性分析及动物实验样本评估等非临床研究场景，为骨生物学研究提供可靠工具。
别名：

Cross-linked Carboxy-terminal telopeptide of type 1 collagen, CTX-1, Cross-linked Carboxy-terminal telopeptide of type I collagen, CTX-I
缩写：

CTX-I
种属：

Homo sapiens (Human)
样本类型：

serum, plasma, tissue homogenates
检测范围：

0.625 ng/mL-40 ng/mL
灵敏度：

0.156 ng/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Others
测定原理：

quantitative
测定方法：

Sandwich

精密度：

线性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human CTX-I in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	88
	Range %	83-95
1:2	Average %	95
	Range %	91-98
1:4	Average %	97
	Range %	90-103
1:8	Average %	96
	Range %	91-101

回收率：

The recovery of human CTX-I spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	85	81-92
EDTA plasma (n=4)	96	93-106

标准曲线：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ng/ml	OD1	OD2	Average	Corrected
40	2.995	2.960	2.978	2.838
20	2.557	2.570	2.564	2.424
10	1.666	1.765	1.716	1.576
5	0.839	0.886	0.863	0.723
2.5	0.491	0.524	0.508	0.368
1.25	0.263	0.251	0.257	0.117
0.625	0.201	0.212	0.207	0.067
0	0.138	0.142	0.140

数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

GPR37 Activation Alleviates Bone Cancer Pain via the Inhibition of Osteoclastogenesis and Neuronal Hyperexcitability K Wang, Y Zhang, R Shu, L Yuan, H Tu,Advanced Science,2025
C-terminal cross-linking telopeptide levels in COVID-19 patients: A prospective case-control study MA Gul,Advances in clinical and experimental medicine,2024
ERK-estrogen receptor α signaling plays a role in the process of bone marrow mesenchymal stem cell-derived exosomes protecting against ovariectomy-induced bone loss H Qi,Journal of orthopaedic surgery and research,2023
Effect of polyhydroxy-terminated PAMAM dendrimer on dentin matrix metalloproteinases within the hybrid layers Y Luo,BMC oral health,2023
Rosiglitazone Mitigates Dexamethasone-Induced Depression in Mice via Modulating Brain Glucose Metabolism and AMPK/mTOR Signaling Pathway A Alhaddad,Biomedicines,2023
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TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling W Yang,Bone Research,2021
Umbilical cord N-terminal procollagen of type l collagen (P1NP) and beta C-terminal telopeptide (βCTX) levels in term pregnancies with vitamin D deficiency M Eraslan Sahin,Journal Gynecological Endocrinology,2020
Efficacy and Safety of Kudzu Flower–Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial JE Kim,Nutrients,2020
Association between bile acid metabolism and bone mineral density in postmenopausal women Zhao YX,Clinics (Sao Paulo),2020
The inhibitory effect of carboxyl-terminated polyamidoamine dendrimers on dentine host-derived matrix metalloproteinases in vitro in an etch-and-rinse adhesive system Wu Q, et al,Royal Society Open Science,2019
The Circadian Gene Clock Regulates Bone Formation Via PDIA3 Yuan G.et al,J Bone Miner Res. ,2016
Effect of Vitamin D on Peripheral Blood Mononuclear Cells from Patients with Psoriasis Vulgaris and Psoriatic Arthritis Cubillos S.et al,PLoS One.,2016
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Alteration of Cartilage Degeneration and Inflammation Markers in Temporomandibular Joint Osteoarthritis Occurs Proportionally Vos LM et al,J Oral Maxillofac Surg,2013

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Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.