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中文名称：人补体C1q肿瘤坏死因子相关蛋白6(C1QTNF6)酶联免疫试剂盒
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货号：CSB-EL003651HU
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规格：96T/48T
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价格：￥3600/￥2500
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其他：
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产品描述：人补体C1q肿瘤坏死因子相关蛋白6（C1QTNF6）是CTRP蛋白家族成员之一，参与代谢调节、炎症反应及细胞增殖等生物学过程。本试剂盒（货号：CSB-EL003651HU）采用双抗体夹心酶联免疫吸附法（ELISA），可定量检测人血清、血浆或组织匀浆样本中的C1QTNF6蛋白，检测灵敏度为0.312 ng/mL，线性范围为0.312-20 ng/mL，支持低至50 μL的样本量要求。该试剂盒包含预包被特异性抗体的酶标板、标准品、检测抗体及显色系统，通过高特异性抗体配对确保检测准确性，适用于细胞培养上清或生物样本中C1QTNF6蛋白水平的定量分析。科研人员可将其应用于代谢性疾病机制研究、慢性炎症相关信号通路探索，或肿瘤微环境中细胞因子调控等领域，为揭示C1QTNF6在疾病发生发展中的功能提供可靠工具。实验操作全程约需4.5小时，建议用户通过标准曲线绘制实现目标蛋白的精确定量，实验结果需结合多孔板读数仪在450 nm波长下分析。
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别名：C1q and tumor necrosis factor related protein 6 ELISA Kit; C1QT6_HUMAN ELISA Kit; C1qtnf6 ELISA Kit; Complement C1q tumor necrosis factor related protein 6 ELISA Kit; Complement C1q tumor necrosis factor-related protein 6 ELISA Kit; CTRP 6 ELISA Kit; CTRP6 ELISA Kit; OTTHUMP00000197772 ELISA Kit; OTTHUMP00000197774 ELISA Kit; PRO1151 ELISA Kit; UNQ581 ELISA Kit; ZACRP6 ELISA Kit
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缩写：C1QTNF6
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Uniprot No.：
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种属：Homo sapiens (Human)
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样本类型：serum, plasma, tissue homogenates
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检测范围：0.312 ng/mL-20 ng/mL
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灵敏度：0.078 ng/mL
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Others
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测定原理：quantitative
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测定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
线性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human C1QTNF6 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 97 Range % 92-101 1:2 Average % 105 Range % 99-108 1:4 Average % 90 Range % 84-94 1:8 Average % 87 Range % 82-91 -
回收率：
The recovery of human C1QTNF6 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 92 85-96 EDTA plasma (n=4) 90 82-93 -
标准曲线：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
ng/ml OD1 OD2 Average Corrected 20 2.778 2.662 2.720 2.600 10 1.926 1.905 1.916 1.796 5 1.315 1.342 1.329 1.209 2.5 0.703 0.734 0.719 0.599 1.25 0.390 0.381 0.386 0.266 0.625 0.295 0.288 0.292 0.172 0.312 0.203 0.209 0.206 0.086 0 0.119 0.121 0.120 -
数据处理：
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货期：3-5 working days
引用文献
- Role of C1q/TNF-Related Protein 6 for the Evaluation of Coronary Heart Disease Associated with Type 2 Diabetes M Li,Therapeutics and clinical risk management,2024
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基因功能参考文献：
- The results establish CTRP6 as a novel metabolic/immune regulator linking obesity to adipose tissue inflammation and insulin resistance. PMID: 28726640
- We found both the rs229527 allele within C1QTNF6 (odds ratio [OR] = 1.23, confidence interval [95% CI]: 1.12-1.33, pAllelic = 4.60 . 10-6) and the rs2284038 allele within RAC2 (OR = 1.10, 95% CI: 1.01-0.19, pAllelic = 3.00 . 10-2) showed significant associations with Graves' Disease susceptibility. PMID: 28665696
- CTRP6 expression was decreased in scar tissues and TGF-beta1-treated dermal fibroblasts. CTRP6 inhibits TGF-beta1-induced the proliferation of dermal fibroblasts. PMID: 27155158
- CTRP6 inhibits the proliferation and migration of ovarian cancer cells via blocking IL-8/VEGF pathway. PMID: 26648301
- CTRP6 is expressed in human synoviocytes, and CTRP6 levels are increased in RA patients. PMID: 26404464
- C1qTNF6 is overexpressed and possibly contributes to tumor angiogenesis by activating the Akt pathway in many hepatocellular carcinomas. PMID: 21508531
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亚细胞定位：Secreted.
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