Human Cardiotrophin-like cytokine factor 1(CLCF1) ELISA kit
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中文名称：人心脏营养素样细胞因子1(CLCF1)酶联免疫试剂盒
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货号：CSB-EL005479HU
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规格：96T/48T
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价格：￥3600/￥2500
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其他：
产品详情
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产品描述：人心脏营养素样细胞因子1(CLCF1)酶联免疫试剂盒（CSB-EL005479HU）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织培养上清液、组织匀浆样本中的CLCF1含量。CLCF1即睫状神经营养因子样细胞因子1，在人体生理和病理过程中发挥一定作用。研究聚焦于其参与的细胞信号传导通路，如与受体结合介导的信号传递，探寻其在神经发育、免疫调节及疾病发生发展等方面机制，以助力相关疾病治疗靶点开发。试剂盒检测范围为0.312 ng/mL-20 ng/mL，该产品可满足体外实验中对CLCF1蛋白表达量的精准检测需求，支持心血管疾病机制研究、炎症信号通路分析以及药物开发中的生物标志物探索等科研场景，尤其适用于细胞模型、动物实验或临床前研究中相关样本的定量检测。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
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别名：B cell stimulating factor 3 ELISA Kit; B-cell-stimulating factor 3 ELISA Kit; BSF 3 ELISA Kit; BSF-3 ELISA Kit; BSF3 ELISA Kit; Cardiotrophin like cytokine ELISA Kit; Cardiotrophin like cytokine factor 1 ELISA Kit; Cardiotrophin-like cytokine factor 1 ELISA Kit; CISS 2 ELISA Kit; CISS2 ELISA Kit; CLC ELISA Kit; CLCF 1 ELISA Kit; Clcf1 ELISA Kit; CLCF1_HUMAN ELISA Kit; Cold induced sweating syndrome 2 ELISA Kit; CRLF 1 associated cytokine like factor 1 ELISA Kit; CRLF1 associated cytokine like factor 1 ELISA Kit; Neurotrophin 1 ELISA Kit; Neurotrophin 1/B cell stimulating factor 3 ELISA Kit; Neurotrophin1 ELISA Kit; NNT 1 ELISA Kit; NNT-1 ELISA Kit; Novel neurotrophin 1 ELISA Kit; Novel neurotrophin-1 ELISA Kit; NR 6 ELISA Kit; NR6 ELISA Kit
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缩写：CLCF1
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Uniprot No.：
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种属：Homo sapiens (Human)
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样本类型：serum, plasma, cell culture supernates, tissue homogenates
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检测范围：0.312 ng/mL-20 ng/mL
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灵敏度：0.078 ng/mL
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Others
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测定原理：quantitative
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测定方法：Sandwich
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数据处理：
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货期：3-5 working days
产品评价
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靶点详情
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功能：In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
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基因功能参考文献：
- CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
- Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. PMID: 26198769
- albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 complex. PMID: 25843671
- activation of the Jak-STAT cascade is essential for corticotroph NNT-1/BSF-3 signaling. PMID: 12639901
- Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
- Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain PMID: 18728012
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相关疾病：Cold-induced sweating syndrome 2 (CISS2)
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亚细胞定位：Secreted.
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蛋白家族：IL-6 superfamily
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组织特异性：Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
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数据库链接：
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