Human C-C motif chemokine 14(CCL14) ELISA kit
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中文名称：人CC趋化因子14(CCL14)酶联免疫试剂盒
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货号：CSB-EL004777HU
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规格：96T/48T
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价格：￥3600/￥2500
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其他：
产品详情
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产品描述：CUSABIO人CC趋化因子14（CCL14）酶联免疫检测试剂盒（货号CSB-EL004777HU），采用双抗体夹心法进行定量分析，能够精准检测血清、血浆及组织匀浆样本中CCL14的蛋白表达水平。CCL14属于CC亚家族趋化因子成员，通过与特定受体结合参与炎症反应调节、免疫细胞迁移及组织修复等生物学过程，其表达水平变化与多种病理生理状态相关。试剂盒检测范围为0.156-10 ng/mL，灵敏度达0.156 ng/mL，提供预包被特异性抗体的96孔板及配套标准品、检测抗体、显色底物等核心组分，操作时通过标准曲线比对实现目标蛋白的准确定量。该试剂盒适用于体外实验中对CCL14蛋白的定量检测，可用于探究其在炎症性疾病、免疫调节异常或肿瘤微环境中的表达特征，为细胞信号通路研究、疾病模型构建或药物作用机制分析等科研项目提供可靠的数据支持。
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别名：CC-1 ELISA Kit; CC-3 ELISA Kit; CCL14 ELISA Kit; CCL14_HUMAN ELISA Kit; chemokine (C-C motif) ligand 14 ELISA Kit; Chemokine CC-1/CC-3 ELISA Kit; chemokine CC1 ELISA Kit; chemokine CC3 ELISA Kit; chemokine HCC1 ELISA Kit; chemokine HCC3 ELISA Kit; CKb1 ELISA Kit; HCC 1 ELISA Kit; HCC 3 ELISA Kit; HCC-1(1-74) ELISA Kit; HCC-1(9-74) ELISA Kit; HCC-1/HCC-3 ELISA Kit; HCC-3 ELISA Kit; HCC1 ELISA Kit; HEMOFILTRATE CC CHEMOKINE 1 ELISA Kit; MCIF ELISA Kit; NCC-2 ELISA Kit; NCC2 ELISA Kit; new CC chemokine 2 ELISA Kit; SCYA14 ELISA Kit; SCYL2 ELISA Kit; small inducible cytokine subfamily A (Cys-Cys); member 14 ELISA Kit; Small-inducible cytokine A14 ELISA Kit; SY14 ELISA Kit
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缩写：
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Uniprot No.：
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种属：Homo sapiens (Human)
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样本类型：serum, plasma, tissue homogenates
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检测范围：0.156 ng/mL-10 ng/mL
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灵敏度：0.039 ng/mL
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Immunology
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测定原理：quantitative
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测定方法：Sandwich
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数据处理：
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货期：3-5 working days
引用文献
- Serum proteomics identifies S100A11 and MMP9 as novel biomarkers for predicting the early efficacy of sublingual immunotherapy in allergic rhinitis Y Zhang,International immunopharmacology,2023
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靶点详情
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功能：Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
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基因功能参考文献：
- TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival PMID: 28718365
- CCL14 is a critical mediator of the JARID1B/LSD1/NuRD complex in regulation of angiogenesis and metastasis in breast cancer. PMID: 21937684
- enhanced expression in intestinal epithelium in inflammatory bowel disease and display of antibacterial activity PMID: 19812544
- Functional data from activity assays by intracellular calcium flux and inhibition of CCR5-mediated HIV-1 entry show that only CCL14 [9-74] is fully active at these near-physiological concentrations where CCL14 [9-74] is monomeric and CCL14 is dimeric PMID: 17691823
- CCL14 is involved in mechanisms by which trophoblast cells migrate during early pregnancy. PMID: 18367676
- SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype. PMID: 18602166
- the activity of CCL14a might be regulated by stringent proteolytic activation and inactivation steps PMID: 19553544
- D6 cooperates with CD26 in the negative regulation of CCL14 by the selective degradation of its biologically active isoform. PMID: 19632987
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亚细胞定位：Secreted.
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蛋白家族：Intercrine beta (chemokine CC) family
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组织特异性：Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
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数据库链接：
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