Bovine Angiopoietin-1(ANGPT1) ELISA kit

    血管生成素1（ANGPT1）是一种血管生成素家族成员，与血管生成、血管增生和血管通透性调节有关。最新的研究表明，ANGPT1在心血管系统、免疫系统、肿瘤学等领域中都具有重要作用，并且可能是潜在的治疗靶点。研究人员正在探索ANGPT1与其相关的信号通路，以便更好地了解其生物学功能和作为治疗靶点的潜力。

Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.

1. Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. PMID: 27216150
2. ANPT-1 becomes predominant in the follicle producing high levels of E(2), indicating the possible switch-over from ANPT-2 (antagonist) to ANPT-1 (agonist). PMID: 15329480
3. inhibition of NO production by Ang-1, via phosphorylation of eNOS on Thr(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF-stimulated endothelial permeability by Ang-1. PMID: 19564638

Secreted.

KEGG: bta:282140

UniGene: Bt.91353