HK2
HK2，即己糖激酶2，别名包括HKⅡ、HXK2。HK2由人类HK2基因编码。HK2是一种关键的代谢酶，主要定位在线粒体外膜上，负责催化糖酵解途径中的第一步反应，将葡萄糖磷酸化为6-磷酸葡萄糖。HK2在许多肿瘤中都呈现出高表达，在促进Warburg效应产生上起到重要作用，Warburg效应即肿瘤细胞倾向于通过糖酵解而非氧化磷酸化来产生能量。HK2作为一个葡萄糖感受器，感应细胞内葡萄糖水平，通过经典与非经典的功能的转换以连接能量代谢与肿瘤免疫，揭示了Warburg效应促进肿瘤免疫逃逸的机制。该研究不仅为癌症的个体化治疗揭示了新的代谢标记物和分子靶点，而且对靶向肿瘤代谢和肿瘤免疫的药物研发具有重要的指导意义。
热销产品
HK2 Antibody (CSB-PA010469LA01HU)
验证数据
Western Blot
Positive WB detected in: U87 whole cell lysate
All lanes: HK2 antibody at 4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 103 kDa
Observed band size: 103 kDa
Immunofluorescent analysis of PC-3 cells using CSB-PA010469LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
HK2 Antibodies
HK2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA611310 | HK2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA132121 | HK2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010469LA01HU | HK2 Antibody | Human | ELISA, WB, IF |
| CSB-PA010469LB01HU | HK2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010469LC01HU | HK2 Antibody, FITC conjugated | Human | |
| CSB-PA010469LD01HU | HK2 Antibody, Biotin conjugated | Human | ELISA |
HK2 Proteins
HK2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010469RA CSB-EP010469RA CSB-BP010469RA CSB-MP010469RA CSB-EP010469RA-B |
Recombinant Rat Hexokinase-2 (Hk2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010469HU CSB-EP010469HU CSB-BP010469HU CSB-MP010469HU CSB-EP010469HU-B |
Recombinant Human Hexokinase-2 (HK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Equus caballus (Horse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010469HO CSB-EP010469HO CSB-BP010469HO CSB-MP010469HO CSB-EP010469HO-B |
Recombinant Horse Hexokinase-2 (HK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010469MO CSB-EP010469MO CSB-BP010469MO CSB-MP010469MO CSB-EP010469MO-B |
Recombinant Mouse Hexokinase-2 (Hk2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Equus zebra (Mountain zebra)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010469EJC CSB-EP010469EJC CSB-BP010469EJC CSB-MP010469EJC CSB-EP010469EJC-B |
Recombinant Equus zebra Hexokinase-2 (HK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Equus grevyi (Grevy's zebra)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010469EJB CSB-EP010469EJB CSB-BP010469EJB CSB-MP010469EJB CSB-EP010469EJB-B |
Recombinant Equus grevyi Hexokinase-2 (HK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HK2 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP633529PI CSB-EP633529PI CSB-BP633529PI CSB-MP633529PI CSB-EP633529PI-B |
Recombinant Pig Hexokinase-2 (HK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
