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  4. Recombinant Macaca fascicularis Reticulon-4 receptor (RTN4R)

Recombinant Macaca fascicularis Reticulon-4 receptor (RTN4R)

  • 中文名称：
    猕猴RTN4R重组蛋白
  • 货号：
    CSB-YP868223MOV
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    猕猴RTN4R重组蛋白
  • 货号：
    CSB-EP868223MOV
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    猕猴RTN4R重组蛋白
  • 货号：
    CSB-EP868223MOV-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    猕猴RTN4R重组蛋白
  • 货号：
    CSB-BP868223MOV
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    猕猴RTN4R重组蛋白
  • 货号：
    CSB-MP868223MOV
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RTN4R
  • Uniprot No.：
    Q9N0E3
  • 别名：
    RTN4R; NOGOR; QccE-10286; Reticulon-4 receptor; Nogo receptor; NgR; Nogo-66 receptor
  • 种属：
    Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-447
  • 氨基酸序列
    CPGA CVCYNEPKVT TSCPQQGLQA VPAGIPASSQ RIFLHGNRIS HVPAASFRAC RNLTILWLHS NVLARIDAAA FAGLALLEQL DLSDNAQLRS VDPATFHGLG RLHTLHLDRC GLQELGPGLF RGLAALQYLY LQDNALQALP DDTFRDLGNL THLFLHGNRI SSVPERAFRG LHSLDRLLLH QNRVAHVHPH AFRDLGRLMT LYLFRNNLSA LPAEALAPLR ALQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCSLP QRLAGRDLKR LAANDLQGCA VATGPCHPIW TGRATDEELL GLPKCCQPDA ADKASVLEPG RPASAGNALK GRVPPGDSPP GNGSGPRHIN DSPFGTLPGS AEPPLTAVRP EGSEPPGFPT SGPRRRPGCS RKNRTRSHCR LGQAGSGGGG TGDSEGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Interacts with OMG.
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon.
  • 蛋白家族：
    Nogo receptor family
  • 数据库链接：

    KEGG: mcf:102139327

    UniGene: Mfa.6428

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