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  4. Recombinant Human Serine/threonine-protein kinase PRP4 homolog (PRPF4B), partial

Recombinant Human Serine/threonine-protein kinase PRP4 homolog (PRPF4B), partial

  • 中文名称：
    人PRPF4B重组蛋白
  • 货号：
    CSB-YP614426HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PRPF4B重组蛋白
  • 货号：
    CSB-EP614426HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PRPF4B重组蛋白
  • 货号：
    CSB-EP614426HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PRPF4B重组蛋白
  • 货号：
    CSB-BP614426HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PRPF4B重组蛋白
  • 货号：
    CSB-MP614426HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PRPF4B
  • Uniprot No.：
    Q13523
  • 别名：
    dJ1013A10.1 (PRP4 protein kinase homolog); dJ1013A10.1; KIAA0536; PR4H; Protein serine/threonine kinase; PRP4; PRP4 kinase; PRP4 pre mRNA processing factor 4 homolog; PRP4 pre mRNA processing factor 4 homolog B (yeast); PRP4 pre-mRNA-processing factor 4 homolog; PRP4B_HUMAN; PRP4H; PRP4K; PRPF4B; Serine/threonine protein kinase PRP4 homolog ; Serine/threonine-protein kinase PRP4 homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
  • 基因功能参考文献：
    1. PRP4K inhibits proliferation and invasiveness of cultured breast cancer cells and its high expression correlates with good prognosis in breast cancer patients. PMID: 29695716
    2. Study identifies a novel role for PRP4K in regulating the endosomal trafficking of EGFR leading to altered anoikis sensitivity in epithelial cancer cells. PMID: 28892043
    3. Results from a study on gene expression variability markers in early-stage human embryos shows that PRPF4B is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    4. Low PRP4K expression correlates with significantly worse overall survival in high-grade serous ovarian cancer, and its depletion increased metastasis in the mouse ID8 ovarian carcinoma model and promoted both sustained growth factor signalling in detached conditions and anoikis resistance in human cervical, breast and ovarian cancer cells. PMID: 28892043
    5. PRP4K is novel estrogen regulated kinase, and its levels can be reduced by 4-OHT in ER+ breast cancer cells altering their response to taxanes PMID: 26712520
    6. PRP4K functions as a HER2-regulated modifier of taxane sensitivity that may have prognostic value as a marker of better overall survival in taxane-treated ovarian cancer patients. PMID: 25602630
    7. PRP4K functions as a HER2-regulated modifier of taxane sensitivity and is a prognostic biomarker for better survival in taxane-treated ovarian cancer patients. PRP4K knock-down results in "mitotic slippage" in response to taxanes, and reduced PRP4K expression is associated with both intrinsic and acquired resistance of ovarian and breast cancers to taxanes. PMID: 25602630
    8. expression and activity are closely associated with the survival and regulation of apoptotic events in colon cancer cells PMID: 23686430
    9. data indicate that miR-371-5p, which is highly expressed in hepatocellular carcinoma, promotes the growth of HCC cells in vitro and in vivo by activating cell cycle progression at the G1/S checkpoint by directly targeting PRPF4B PMID: 23466643
    10. The authors provide evidence that PRP6 and PRP31 are directly phosphorylated by human PRP4 kinase (PRP4K) concomitant with their incorporation into B complexes. PMID: 20118938
    11. Short-term exercise resulted in a significant increase of mRNA expression of genes encoding proteins involved in the formation of precatalytic splisosome: PRPF4B. PMID: 19902070
    12. Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. PMID: 12077342
    13. interacts specifically with HIV-2 gag PMID: 15452250
    14. PRP4, a serine/threonine protein kinase, is identified as a Kruppel-like factor 13 (KLF13)-binding protein; PRP4 phosphorylates KLF13 PMID: 17513757

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 17346

    OMIM: 602338

    KEGG: hsa:8899

    STRING: 9606.ENSP00000337194

    UniGene: Hs.159014

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